{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:39:42Z","timestamp":1791175182122,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"vor","delay-in-days":108,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Conquering cardiovascular diseases is one of the most important problems in human health. To overcome cardiovascular diseases, animal models have played important roles. Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way. In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function. On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits. One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low\u2010density lipoprotein (LDL) receptor. The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction\u2010prone WHHL (WHHLMI) rabbit. This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and\/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits.<\/jats:p>","DOI":"10.1155\/2011\/406473","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T15:34:17Z","timestamp":1303227257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases"],"prefix":"10.1155","volume":"2011","author":[{"given":"Tsutomu","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Shiomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"The World Health Report 2002\u2014Reducing Risks, Promoting Healthy Life: Statistical Annex","author":"World Health Organization","year":"2002"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.14.45"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.10.1774"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.1346"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(86)90117-7"},{"key":"e_1_2_9_6_2","first-page":"99","article-title":"Studies on characteristic of spontaneously hyperlipidemic rabbit and development of the strain with such property","volume":"2","author":"Watanabe Y.","year":"1977","journal-title":"Bulletin of Azabu Veterinary College"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-008-0023-1"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.024"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim1957.26.1_35"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(80)90234-8"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)81223-3"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.2.6.467"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.18.5693"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3623"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37988-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90085-1"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90036-G"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000075947.28567.50"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283189c18"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.6.931"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)80025-6"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.53.339"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(88)90282-2"},{"key":"e_1_2_9_24_2","first-page":"815","article-title":"Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit","volume":"135","author":"Boyd H. 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