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Destruction of lacrimal and salivary glands by autoimmune reactions may lead to clinical manifestation. However, the mechanisms behind the decreased volume of secretions in tears and saliva are complex and are not fully understood. Exocrine gland dysfunction may precede autoimmunity (acquired immunity) or represent a process independent from inflammation in the pathogenesis of SjS. The preceded functional and morphologic changes of those tissues by nonimmunologic injury before the development of inflammation at the sites of target organs have been implicated. This paper focuses on the several factors and components relating to glandular dysfunction and morphologic changes by nonimmunologic injury during the preinflammatory phase in mouse model, including the factors which link between innate immunity and adaptive immunity.<\/jats:p>","DOI":"10.1155\/2011\/407031","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T19:34:36Z","timestamp":1306956876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Dysfunction of Lacrimal and Salivary   Glands in Sj\u00f6gren\u2032s Syndrome: Nonimmunologic Injury in   Preinflammatory Phase and Mouse Model"],"prefix":"10.1155","volume":"2011","author":[{"given":"Toshiharu","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.045"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_6_3_2","first-page":"105","article-title":"Sjogren\u2032s syndrome in relation to other autoimmune diseases","volume":"40","author":"Feltkamp T. 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