{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:08:11Z","timestamp":1740103691886,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Study Objective<\/jats:italic>. To identify sensitive and specific histological criteria for endometritis in women with laparoscopically-confirmed acute salpingitis.<jats:italic>Methods<\/jats:italic>. Women, age 18\u201340 years of age presenting with complaints of lower abdominal pain \u22642 weeks and no antibiotics use in past two weeks, were enrolled. They underwent clinical examination, screening for HIV; other sexually transmitted infections plus endometrial biopsy sampling for histopathology. Diagnostic laparoscopy confirmed the diagnosis of acute salpingitis. Controls were women undergoing tubal ligation and HIV-1 infected women asymptomatic for genital tract infection.<jats:italic>Results<\/jats:italic>. Of 125 women with laparoscopically-confirmed salpingitis, 38% were HIV-1 seropositive. Nineteen HIV-1 negative controls were recruited. For the diagnosis of endometritis, \u22651 plasma cells (PC) and \u22653 polymorphonuclear lymphocytes (PMN) per HPF in the endometrium had a sensitivity of 74% for HIV-1-seropositive, 63% for HIV-1-seronegative women with a specificity of 75% and positive predictive value of 85% regardless of HIV-1-infection for predicting moderate to severe salpingitis. For HIV-1-seronegative women with mild salpingitis, \u22651 PC and \u22653 PMN had a sensitivity of 16% and a PPV of 57%.<jats:italic>Conclusion<\/jats:italic>. Endometrial histology, did not perform well as a surrogate marker for moderate to severe salpingitis, and failed as a surrogate marker for mild salpingitis.<\/jats:p>","DOI":"10.1155\/2011\/407057","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T19:23:48Z","timestamp":1316546628000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Endometrial Histopathology in Patients with Laparoscopic Proven Salpingitis and HIV-1 Infection"],"prefix":"10.1155","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-006X","authenticated-orcid":true,"given":"Nelly R.","family":"Mugo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kenyatta National Hospital, P.O. Box 19865-00202, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kiehlbauch","sequence":"additional","affiliation":[{"name":"Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Department of Pathology, Harborview Medical Center, UW Medicine Pathology, University of Washington, P.O. Box 357470, Seattle, WA 98195-7470, USA"},{"name":"Maryland Department of Health and Mental Hygiene, 201 West Preston Street, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Kiviat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harborview Medical Center, UW Medicine Pathology, University of Washington, P.O. Box 357470, Seattle, WA 98195-7470, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Nguti","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Nairobi, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Gichuhi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kenyatta National Hospital, P.O. Box 19865-00202, Nairobi, Kenya"},{"name":"Department of Obstetrics and Gynecology, University of Nairobi, School of Medicine, Kenyatta National Hospital, P.O. Box 19676, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter E.","family":"Stamm","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-6634","authenticated-orcid":true,"given":"Craig R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya"},{"name":"Department of Obstetrics and Gynecology, University of Nairobi, School of Medicine, Kenyatta National Hospital, P.O. 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