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This has been attributed to several strategies by which<jats:italic>C. trachomatis<\/jats:italic>evades immune detection, including well-described methods by which<jats:italic>C. trachomatis<\/jats:italic>decreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence of<jats:italic>C. trachomatis<\/jats:italic>is mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread of<jats:italic>C. trachomatis<\/jats:italic>genital infections.<\/jats:p>","DOI":"10.1155\/2011\/420905","type":"journal-article","created":{"date-parts":[[2011,5,29]],"date-time":"2011-05-29T19:34:17Z","timestamp":1306697657000},"page":"1-8","source":"Crossref","is-referenced-by-count":25,"title":["<i>Chlamydia trachomatis<\/i>Immune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms"],"prefix":"10.1155","volume":"2011","author":[{"given":"Joyce A.","family":"Ibana","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny J.","family":"Schust","sequence":"additional","affiliation":[{"name":"Department 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