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Considering that opioids were known to inhibit immune function, the present study was designed to observe whether EA could modulate the immune status of morphine dependent and withdrawal mice. We found that chronic morphine\u2010induced decrease of splenic T lymphocyte proliferation and IL\u20102 production can be significantly raised by 2\u2009Hz EA, and the fluctuation of CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup>ratio was also run to the baseline level by the EA. These findings indicated that chronic morphine exposure\u2010induced immune dysfunction in mice could be normalized by 2\u2009Hz EA.<\/jats:p>","DOI":"10.1155\/2011\/424092","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T07:17:41Z","timestamp":1307690261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Damage of Splenic T Lymphocyte Proliferation and Differentiation and Its Normalization by Electroacupuncture in Morphine\u2010Dependent Mice Mode"],"prefix":"10.1155","volume":"2011","author":[{"given":"Hong-Yu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Lian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu-Zhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2010.00561.x"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005\u2010008\u20100035\u20100"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2008.01688.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481\u2010009\u20109184\u20100"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.08.016"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.12.005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.03.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167\u20100115(94)90416\u20102"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(99)02069\u20107"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20103908(90)90096\u2010A"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(97)01529\u20101"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0022-3565(25)13105-4","article-title":"Evidence for the involvement of the caudal region of the periaqueductal gray in a subset of morphine-induced alterations of immune status","volume":"277","author":"Lysle D. 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