{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T06:35:34Z","timestamp":1721284534229},"reference-count":62,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Electrical and Computer Engineering"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. AIDA is an interactive educational diabetes simulator available on the Internet without charge since 1996 (accessible at: http:\/\/www.2aida.org\/). Since the program\u2019s original release, users have developed new requirements, with new operating systems coming into use and more complex insulin management regimens being adopted. The current work has aimed to design a comprehensive diabetes simulation system from both a clinical and information technology perspective.<jats:italic>Methods<\/jats:italic>. A collaborative development is taking place with a new generic model of subcutaneous insulin absorption, permitting the simulation of rapidly-acting and very long-acting insulin analogues, as well as insulin injections larger than 40 units. This novel, physiological insulin absorption model has been incorporated into AIDA v4. Technical work has also been undertaken to install and operate the AIDA software within a DOSBox emulator, to ensure compatibility with Windows XP, Vista and 7 operating systems as well as Apple Macintosh computers running Parallels PC emulation software.<jats:italic>Results<\/jats:italic>. Plasma insulin simulations are demonstrated following subcutaneous injections of a rapidly-acting insulin analogue, a short-acting insulin preparation, intermediate-acting insulin, and a very long-acting insulin analogue for injected insulin doses up to 60 units of insulin.<jats:italic>Discussion.<\/jats:italic>The current work extends the useful life of the existing AIDA v4 program.<\/jats:p>","DOI":"10.1155\/2011\/427196","type":"journal-article","created":{"date-parts":[[2011,3,20]],"date-time":"2011-03-20T19:32:48Z","timestamp":1300649568000},"page":"1-17","source":"Crossref","is-referenced-by-count":11,"title":["Development of AIDA v4.3b Diabetes Simulator: Technical Upgrade to Support Incorporation of Lispro, Aspart, and Glargine Insulin Analogues"],"prefix":"10.1155","volume":"2011","author":[{"given":"Eldon D.","family":"Lehmann","sequence":"first","affiliation":[{"name":"Department of Imaging (MRU), Imperial College of Science, Technology and Medicine (NHLI), Royal Brompton Hospital, London SW3 6NP, UK"},{"name":"Department of Radiology, Barts and The London NHS Trust, Royal London Hospital, Whitechapel, London E1 1BB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Tar\u00edn","sequence":"additional","affiliation":[{"name":"Institute for Systems Dynamics, University of Stuttgart, 70569 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Bondia","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Autom\u00e1tica e Inform\u00e1tica Industrial, Universidad Polit\u00e9cnica de Valencia, 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Teufel","sequence":"additional","affiliation":[{"name":"Campus Vaihingen, University of Stuttgart, 70569 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Informatics and Medical Technology, Faculty of Health Sciences, Semmelweis University, Budapest 1088, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"4","key":"1a","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/14639239608999287","volume":"21","year":"1996","journal-title":"Medical Informatics"},{"issue":"1","key":"1b","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/14639239709089830","volume":"22","year":"1997","journal-title":"Medical Informatics"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"issue":"6","key":"3","first-page":"470","volume":"25","year":"1983","journal-title":"Diabetologia"},{"issue":"9","key":"4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF00296989","volume":"30","year":"1987","journal-title":"Diabetologia"},{"key":"5","year":"1996"},{"issue":"7367","key":"6","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1136\/bmj.325.7367.746","volume":"325","year":"2002","journal-title":"British Medical Journal"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(99)00074-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-2607(98)00019-4"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/152091599317567","volume":"1","year":"1999","journal-title":"Diabetes Technology &amp; Therapeutics"},{"issue":"6","key":"10","first-page":"380","volume":"12","year":"1999","journal-title":"Diabetes, Nutrition & Metabolism"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/14639239709089834","volume":"22","year":"1997","journal-title":"Medical Informatics"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0933-3657(94)90042-6"},{"issue":"3-4","key":"13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0169-2607(94)90054-X","volume":"41","year":"1994","journal-title":"Computer Methods & Programs in Biomedicine"},{"issue":"3","key":"14a","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/1350-4533(94)90038-8","volume":"16","year":"1994","journal-title":"Medical Engineering and Physics"},{"key":"14b","doi-asserted-by":"publisher","DOI":"10.1016\/1350-4533(94)90064-7"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(96)01751-8"},{"key":"16","year":"1997"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/15209150152607268"},{"issue":"3","key":"19","first-page":"516","volume":"7","year":"2001","journal-title":"Medical Science Monitor"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0141-5425(92)90058-S","volume":"14","year":"1992","journal-title":"Journal of Biomedical Engineering"},{"key":"22a","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.419"},{"key":"22b","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.602"},{"key":"22c","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.0065"},{"issue":"2","key":"23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2337\/diacare.7.2.188","volume":"7","year":"1984","journal-title":"Diabetes Care"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-5056(01)00214-3"},{"issue":"7","key":"25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/bi00328a027","volume":"24","year":"1985","journal-title":"Biochemistry"},{"issue":"12","key":"26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2337\/diab.44.12.1381","volume":"44","year":"1995","journal-title":"Diabetes"},{"issue":"4","key":"27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2337\/diab.32.4.331","volume":"32","year":"1983","journal-title":"Diabetes"},{"issue":"6","key":"28","first-page":"E1115","volume":"269","year":"1995","journal-title":"American Journal of Physiology"},{"issue":"10","key":"29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2337\/diacare.12.10.725","volume":"12","year":"1989","journal-title":"Diabetes Care"},{"issue":"1","key":"30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01059088","volume":"17","year":"1989","journal-title":"Journal of Pharmacokinetics & Biopharmaceutics"},{"issue":"9","key":"31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1515\/bmte.1993.38.9.224","volume":"38","year":"1993","journal-title":"Biomedizinische Technik"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/BF02522939"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.857681"},{"issue":"3","key":"35a","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/193229680700100317","volume":"1","year":"2007","journal-title":"Journal of Diabetes Science & Technology"},{"issue":"5","key":"35b","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/193229680700100525","volume":"1","year":"2007","journal-title":"Journal of Diabetes Science & Technology"},{"key":"35c","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/193229680900300123","volume":"3","year":"2009","journal-title":"Journal of Diabetes Science & Technology"},{"issue":"4","key":"36","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/193229680800200417","volume":"2","year":"2008","journal-title":"Journal of Diabetes Science & Technology"},{"issue":"4","key":"37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/193229680800200418","volume":"2","year":"2008","journal-title":"Journal of Diabetes Science & Technology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2009.6.41"},{"issue":"11","key":"41","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2337\/diacare.14.11.942","volume":"14","year":"1991","journal-title":"Diabetes Care"},{"key":"42","first-page":"163A","volume":"37","year":"1988 [abstract]","journal-title":"Diabetes"},{"issue":"3","key":"43","first-page":"208","volume":"26","year":"1984","journal-title":"Diabetologia"},{"issue":"3","key":"44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1464-5491.1992.tb01769.x","volume":"9","year":"1992","journal-title":"Diabetic Medicine"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90602-2"},{"key":"46","first-page":"1","volume":"27","year":"1969","journal-title":"Acta Pharmacologica et Toxicologica"},{"issue":"3","key":"47","first-page":"504","volume":"7","year":"2001","journal-title":"Medical Science Monitor"},{"key":"48","year":"1981"},{"key":"49","first-page":"59","volume-title":"Simulating human intermediary metabolism: OMNI et al","year":"1986"},{"issue":"12","key":"50","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/diab.38.12.1512","volume":"38","year":"1989","journal-title":"Diabetes"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.893506"},{"issue":"1","key":"52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/014572178901500120","volume":"15","year":"1989","journal-title":"The Diabetes Educator"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(91)90117-V"},{"issue":"1","key":"54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/pdi.1960120109","volume":"12","year":"1995","journal-title":"Practical Diabetes International"},{"issue":"3-4","key":"55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0169-2607(94)90055-8","volume":"41","year":"1994","journal-title":"Computer Methods & Programs in Biomedicine"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-5056(02)00015-1"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(90)90114-O"},{"issue":"3-4","key":"58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0169-2607(94)90056-6","volume":"41","year":"1994","journal-title":"Computer Methods & Programs in Biomedicine"},{"issue":"1","key":"59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/152091599317576","volume":"1","year":"1999","journal-title":"Diabetes Technology &amp; Therapeutics"},{"key":"60","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1520-7560(199905\/06)15:3<226::AID-DMRR33>3.0.CO;2-#","volume":"15","year":"1999","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"3","key":"62","first-page":"207","volume":"32","year":"2004","journal-title":"Biochemical Education"}],"container-title":["Journal of Electrical and Computer Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jece\/2011\/427196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jece\/2011\/427196.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jece\/2011\/427196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T21:19:06Z","timestamp":1497907146000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jece\/2011\/427196\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":62,"alternative-id":["427196","427196"],"URL":"https:\/\/doi.org\/10.1155\/2011\/427196","relation":{},"ISSN":["2090-0147","2090-0155"],"issn-type":[{"value":"2090-0147","type":"print"},{"value":"2090-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}