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Kainic acid (KA) is an epileptogenic and neuroexcitotoxic agent by acting on specific kainate receptors (KARs) in the CNS. KA has been extensively used as a specific agonist for ionotrophic glutamate receptors (iGluRs), for example, KARs, to mimic glutamate excitotoxicity in neurodegenerative models as well as to distinguish other iGluRs such as <jats:italic>\u03b1<\/jats:italic>\u2010amino\u20103\u2010hydroxy\u20105\u2010methylisoxazole\u20104\u2010propionate receptors and N\u2010methyl\u2010D\u2010aspartate receptors. Given the current knowledge of excitotoxicity in neurodegeneration, interventions targeted at modulating excitotoxicity are promising in terms of dealing with neurodegenerative disorders. 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