{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:19:10Z","timestamp":1754486350277},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet. RF was induced surgically. Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH)<jats:sub>2<\/jats:sub>D levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>) with a 2.5-fold increased in rPTH (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>). Severe RF rats and those on a -Ca or -D diet had reduced calcium (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:mrow><\/mml:math>) and 25(OH)D levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.05<\/mml:mn><\/mml:mrow><\/mml:math>), with rPTH increased by 2 (-Ca diet;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.05<\/mml:mn><\/mml:mrow><\/mml:math>), 4 (-D diet;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>), and 20-folds (RF;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>) while 1,25(OH)<jats:sub>2<\/jats:sub>D was high (-Ca diet:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>) or low (-D diet, RF:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>). 25(OH)D and 1,25(OH)<jats:sub>2<\/jats:sub>D were positively and negatively related on the -Ca and -D diets, respectively. rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected. This may be related to the short-time course of this study compared to prior studies.<\/jats:p>","DOI":"10.1155\/2011\/469783","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T19:00:43Z","timestamp":1308769243000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms"],"prefix":"10.1155","volume":"2011","author":[{"given":"Pierre","family":"D'Amour","sequence":"first","affiliation":[{"name":"Centre de Recherche, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), H\u00f4pital Saint-Luc D\u00e9partement de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada H2X 1P1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Centre de Recherche, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), H\u00f4pital Saint-Luc D\u00e9partement de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada H2X 1P1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hornyak","sequence":"additional","affiliation":[{"name":"Scantibodies Laboratory Inc., Santee, CA 92071, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zan","family":"Yang","sequence":"additional","affiliation":[{"name":"Scantibodies Laboratory Inc., Santee, CA 92071, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Cantor","sequence":"additional","affiliation":[{"name":"Scantibodies Laboratory Inc., Santee, CA 92071, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"9","key":"1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jbmr.5650070904","volume":"7","year":"1992","journal-title":"Journal of Bone and Mineral Research"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jbmr.5650090506","volume":"9","year":"1994","journal-title":"Journal of Bone and Mineral Research"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1550133"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00222.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.4.1386"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002532"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.1.171"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.2.413"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.11.3923"},{"issue":"5","key":"10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/clinchem\/46.5.697","volume":"46","year":"2000","journal-title":"Clinical Chemistry"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000180403","volume":"13","year":"1974","journal-title":"Nephron"},{"issue":"4","key":"12","first-page":"288","volume":"64","year":"2005","journal-title":"Clinical Nephrology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000108652"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000081023"},{"issue":"4","key":"15","first-page":"247","volume":"66","year":"2006","journal-title":"Clinical Nephrology"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.07.002"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bj1680009","volume":"168","year":"1977","journal-title":"Biochemical Journal"},{"issue":"1-2","key":"18","first-page":"21","volume":"51","year":"2005","journal-title":"Clinical Laboratory"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","volume":"16","year":"2001","journal-title":"Journal of Bone and Mineral Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.040485"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1628"},{"issue":"2","key":"22","first-page":"E118","volume":"236","year":"1979","journal-title":"The American Journal of Physiology"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/jn\/129.1.188","volume":"129","year":"1999","journal-title":"Journal of Nutrition"},{"issue":"2","key":"24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/ajplegacy.1973.225.2.269","volume":"225","year":"1973","journal-title":"American Journal of Physiology"},{"issue":"4","key":"25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jbmr.5650030410","volume":"3","year":"1988","journal-title":"Journal of Bone and Mineral Research"},{"issue":"6099","key":"26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/325062a0","volume":"325","year":"1987","journal-title":"Nature"},{"issue":"1","key":"27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2265.1992.tb02278.x","volume":"37","year":"1992","journal-title":"Clinical Endocrinology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(90)90036-F"},{"issue":"s23, abstract","key":"29","volume":"19","year":"1996","journal-title":"Clinical and Investigative Medicine"},{"issue":"16","key":"30","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1093\/nar\/23.16.3268","volume":"23","year":"1995","journal-title":"Nucleic Acids Research"},{"issue":"8","key":"31","first-page":"1193","volume":"12","year":"1998","journal-title":"Molecular Endocrinology"},{"issue":"10","key":"32","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/ajcn\/32.10.2052","volume":"32","year":"1979","journal-title":"American Journal of Clinical Nutrition"},{"issue":"3","key":"33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI109516","volume":"64","year":"1979","journal-title":"Journal of Clinical Investigation"},{"issue":"12","key":"34","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.82.12.4270","volume":"82","year":"1985","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1210\/endo-125-1-275","volume":"125","year":"1989","journal-title":"Endocrinology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.5253"},{"issue":"6","key":"37","first-page":"333","volume":"4","year":"1983","journal-title":"Metabolic Bone Disease and Related Research"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1080\/08860220601038637"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.4.1536"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000139492.36400.6C"},{"issue":"5","key":"41","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ki.1996.199","volume":"49","year":"1996","journal-title":"Kidney International"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/ajcn\/37.3.403","volume":"37","year":"1983","journal-title":"American Journal of Clinical Nutrition"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010035"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/469783.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/469783.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/469783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T22:16:33Z","timestamp":1712528193000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ije\/2011\/469783\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":43,"alternative-id":["469783","469783"],"URL":"https:\/\/doi.org\/10.1155\/2011\/469783","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}