{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:22:27Z","timestamp":1790446947949,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Multiple Sclerosis International"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Optical coherence tomography (OCT) uses light interference patterns to produce a cross-sectional image of the retina. It is capable of measuring the unmyelinated axons of the retinal ganglionar cells as they converge on the optic disc. In a disease like multiple sclerosis (MS), in which axonal loss has been identified as an important cause of sustained disability, it may prove an invaluable tool. OCT has demonstrated that axonal loss occurs after each episode of optic neuritis and that the degree of axonal loss is correlated to visual outcomes. Furthermore, axonal loss occurs in MS even in the absence of inflammatory episodes, and the degree of this loss is correlated with the duration of the disease process, with more thinning as the disease advances and in progressive forms. Thus, OCT retinal nerve fiber layer measurements may represent an objective outcome measure with which to evaluate the effect of treatment.<\/jats:p>","DOI":"10.1155\/2011\/472790","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T11:25:38Z","timestamp":1307100338000},"page":"1-11","source":"Crossref","is-referenced-by-count":22,"title":["Optical Coherence Tomography in Multiple Sclerosis and Neuromyelitis Optica: An Update"],"prefix":"10.1155","volume":"2011","author":[{"given":"Susana","family":"Noval","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Hospital La Paz\/Aut\u00f3noma University School of Medicine, IdiPAZ, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Contreras","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Clinica Rementer\u00eda, Hospital Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Oreja-Guevara","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital La Paz\/Aut\u00f3noma University School of Medicine, IdiPAZ, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Manzano","sequence":"additional","affiliation":[{"name":"Hospital La Paz\/Aut\u00f3noma University School of Medicine, IdiPAZ, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Rebolleda","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Ram\u00f3n y Cajal, Alcal\u00e1 de Henares University, IRYCIS, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510371640"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70168-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.727"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1326-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00724.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508091367"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.024"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21474"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"issue":"11","key":"12","first-page":"2520","volume":"40","year":"1999","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5589-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S13278"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700691"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.117"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01527.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.265"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0834"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.230"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0985-5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3129\/i10-063"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345042.53843.d5"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.04.014"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.10.020"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.010"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181e3dcb3"},{"issue":"1","key":"36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/112067211002000122","volume":"20","year":"2010","journal-title":"European Journal of Ophthalmology"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-4853(10)70030-X"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70573-7"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2008.11.0156"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507087326"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.924"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000294876.49861.dc"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0738"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-007-0538-3"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm285"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509359782"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328331913b"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e3181b56764"},{"issue":"1","key":"38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/112067211002000123","volume":"20","year":"2010","journal-title":"European Journal of Ophthalmology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1344-7"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1815"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.060"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-45"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af78b8"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aaea32"}],"container-title":["Multiple Sclerosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/472790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/472790.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/472790.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T10:51:53Z","timestamp":1560250313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/msi\/2011\/472790\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":50,"alternative-id":["472790","472790"],"URL":"https:\/\/doi.org\/10.1155\/2011\/472790","relation":{},"ISSN":["2090-2654","2090-2662"],"issn-type":[{"value":"2090-2654","type":"print"},{"value":"2090-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}