{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:03:44Z","timestamp":1747307024462,"version":"3.38.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2011,4,6]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The control of severe bronchial asthma, such as corticosteroid-resistant asthma, is difficult. It is also possible that immunosuppressive agents would be effective for bronchial asthma.<jats:italic>Case Summary<\/jats:italic>. A 55-year-old Japanese female presented with severe bronchial asthma controlled with tacrolimus. She had been diagnosed with bronchial asthma during childhood. Her asthma worsened, and a chest radiograph showed atelectasis of the left lung. Bronchoscopy revealed the left main bronchus to be obstructed with viscous sputum consisting of 82% neutrophils and no eosinophils. The atelectasis did not improve with corticosteroid treatment, but was ameliorated by administration of tacrolimus.<jats:italic>Discussion<\/jats:italic>. This patient had severe asthma due to neutrophilic inflammation of the airways. Tacrolimus is effective for treating severe asthma, for example, in corticosteroid-resistant cases.<\/jats:p>","DOI":"10.1155\/2011\/479129","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T19:33:38Z","timestamp":1302118418000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["A Case of Severe Bronchial Asthma Controlled with Tacrolimus"],"prefix":"10.1155","volume":"2011","author":[{"given":"Hirokazu","family":"Taniguchi","sequence":"first","affiliation":[{"name":"The Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Tokui","sequence":"additional","affiliation":[{"name":"The Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Iwata","sequence":"additional","affiliation":[{"name":"The Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Abo","sequence":"additional","affiliation":[{"name":"The Department of Radioloy, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Izumi","sequence":"additional","affiliation":[{"name":"The Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1164\/ajrccm.162.6.ats9-00","volume":"162","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815512"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1164\/ajrccm\/144.5.page","volume":"144","year":"1991","journal-title":"American Review of Respiratory Disease"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00261903"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1164\/ajrccm.160.3.9812110","volume":"160","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1398-9995.1991.tb00590.x","volume":"46","year":"1991","journal-title":"Allergy"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91646-P"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.4049\/jimmunol.129.6.2360","volume":"129","year":"1982","journal-title":"Journal of Immunology"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0031-6997(25)00032-8","volume":"41","year":"1989","journal-title":"Pharmacological Reviews"},{"issue":"9","key":"10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1183\/09031936.95.08091473","volume":"8","year":"1995","journal-title":"European Respiratory Journal"},{"issue":"1","key":"11","first-page":"22","volume":"30","year":"2000","journal-title":"Clinical and Experimental Allergy, Supplement"},{"issue":"9","key":"12","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.4049\/jimmunol.154.9.4719","volume":"154","year":"1995","journal-title":"Journal of Immunology"}],"container-title":["Journal of Allergy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/479129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/479129.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2011\/479129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T22:50:06Z","timestamp":1741128606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ja\/2011\/479129\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,6]]},"references-count":12,"alternative-id":["479129","479129"],"URL":"https:\/\/doi.org\/10.1155\/2011\/479129","relation":{},"ISSN":["1687-9783","1687-9791"],"issn-type":[{"type":"print","value":"1687-9783"},{"type":"electronic","value":"1687-9791"}],"subject":[],"published":{"date-parts":[[2011,4,6]]}}}