{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:26:22Z","timestamp":1761488782330,"version":"3.41.2"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T00:00:00Z","timestamp":1318636800000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>The flatworm \n                  <jats:italic>Schistosoma mansoni<\/jats:italic> is a blood \n                  fluke parasite that causes schistosomiasis, a \n                  debilitating disease that occurs throughout the \n                  developing world. Current schistosomiasis \n                  control strategies are mainly based on \n                  chemotherapy, but many researchers believe that \n                  the best long\u2010term strategy to control \n                  schistosomiasis is through immunization with an \n                  antischistosomiasis vaccine combined with drug \n                  treatment. Several papers on <jats:italic>Schistosoma \n                  mansoni<\/jats:italic> vaccine and drug development \n                  have been published in the past few years, \n                  representing an important field of study. The \n                  advent of technologies that allow large\u2010scale \n                  studies of genes and proteins had a remarkable \n                  impact on the screening of new and potential \n                  vaccine candidates in schistosomiasis. In this \n                  postgenomic scenario, bioinformatic technologies \n                  have emerged as important tools to mine \n                  transcriptomic, genomic, and proteomic databases. \n                  These new perspectives are leading to a new round \n                  of rational vaccine development. Herein, we \n                  discuss different strategies to identify \n                  potential <jats:italic>S. mansoni<\/jats:italic> vaccine \n                  candidates using computational \n                  vaccinology.<\/jats:p>","DOI":"10.1155\/2011\/503068","type":"journal-article","created":{"date-parts":[[2011,10,16]],"date-time":"2011-10-16T07:17:44Z","timestamp":1318749464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Computational Vaccinology: An Important Strategy to Discover New Potential <i>S. mansoni<\/i> Vaccine Candidates"],"prefix":"10.1155","volume":"2011","author":[{"given":"Carina S.","family":"Pinheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente P.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natan R. 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