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The specific HIV-1 cellular immune responses were analyzed in spleen cells. The body weight of the newborn mice was weekly recorded. The frequencies of HIV-specific CD8<jats:sup>+<\/jats:sup>T cells producing IFN-\u03b3 were higher in adult mice vaccinated intradermally and lower in adult and newborn mice vaccinated subcutaneously. In all cases the IFN-\u03b3 production was significantly higher when mice were primed with BCG.HIVA<jats:sup>222<\/jats:sup>compared with BCGwt. When the HIV-specific CTL activity was assessed, the frequencies of specific killing were higher in newborn mice than in adults. The prime-boost vaccination regimen which includes BCG.HIVA<jats:sup>222<\/jats:sup>and MVA.HIVA was safe when inoculated to newborn mice. The administration of BCG.HIVA<jats:sup>222<\/jats:sup>to newborn mice is safe and immunogenic and increased the HIV-specific responses induced by MVA.HIVA vaccine. It might be a good model for infant HIV and Tuberculosis bivalent vaccine.<\/jats:p>","DOI":"10.1155\/2011\/516219","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T19:32:46Z","timestamp":1301513566000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Newborn Mice Vaccination with BCG.HIVA<sup>222<\/sup>+ MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes"],"prefix":"10.1155","volume":"2011","author":[{"given":"Narc\u00eds","family":"Saubi","sequence":"first","affiliation":[{"name":"AIDS Research Unit, Hospital Cl\u00ednic\/IDIBAPS-HIVACAT, University of Barcelona, Calle Villarroel 170, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung-Jun","family":"Im","sequence":"additional","affiliation":[{"name":"MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University and The John Radcliffe, Oxford OX3 9DS, 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