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Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato\/splenomegaly, osteoarticular, and genital infections. Relevant aspects of<jats:italic>Brucella<\/jats:italic>pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by<jats:italic>Brucella<\/jats:italic>. This model is most frequently used to investigate specific pathogenic factors of<jats:italic>Brucella<\/jats:italic>spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.<\/jats:p>","DOI":"10.1155\/2011\/518323","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T20:29:13Z","timestamp":1298233753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Laboratory Animal Models for Brucellosis Research"],"prefix":"10.1155","volume":"2011","author":[{"given":"Teane M. 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