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This distinction is important as it carries implications for evaluation, prognosis, and treatment. Clonal thrombocytosis associated with the myeloproliferative neoplasms, especially essential thrombocythemia and polycythemia vera, carries a unique prognostic profile, with a markedly increased risk of thrombosis. This risk is the driving factor behind treatment strategies in these disorders. Clinical trials utilizing targeted therapies in thrombocytosis are ongoing with new therapeutic targets waiting to be explored. This paper will outline the mechanisms underlying thrombocytosis, the diagnostic evaluation of thrombocytosis, complications of thrombocytosis with a special focus on thrombotic risk as well as treatment options for clonal processes leading to thrombocytosis, including essential thrombocythemia and polycythemia vera.<\/jats:p>","DOI":"10.1155\/2011\/536062","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T16:49:49Z","timestamp":1307551789000},"page":"1-16","source":"Crossref","is-referenced-by-count":112,"title":["Thrombocytosis: Diagnostic Evaluation, Thrombotic Risk Stratification, and Risk-Based Management Strategies"],"prefix":"10.1155","volume":"2011","author":[{"given":"Jonathan S.","family":"Bleeker","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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