{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:53:48Z","timestamp":1776855228476,"version":"3.51.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T00:00:00Z","timestamp":1314576000000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ligue Fran\u00e7aise contre le cancer, Comit\u00e9s Lorrains"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. We aimed to explore (i) the short\u2010term retention of intramedullary implanted mesenchymal stem cells BMSCs and (ii) their impact on the bone blood flow and metabolism in a rat model of hindlimb irradiation. <jats:italic>Methods<\/jats:italic>. Three months after 30 Gy irradiation, fourteen animals were referred into 2 groups: a sham\u2010operated group (<jats:italic>n<\/jats:italic> = \u20096) and a treated group (<jats:italic>n<\/jats:italic> = \u20098) in which <jats:sup>111<\/jats:sup>In\u2010labelled BMSCs (2 \u00d7 10<jats:sup>6<\/jats:sup> cells) were injected in irradiated tibias. Bone blood flow and metabolism were assessed by serial <jats:sub>\u2009<\/jats:sub><jats:sup>99m<\/jats:sup>Tc\u2010HDP scintigraphy and 1\u2010wk cell retention by recordings of <jats:sub>\u2009<\/jats:sub><jats:sup>99m<\/jats:sup>Tc\/<jats:sup>111<\/jats:sup>In activities. <jats:italic>Results<\/jats:italic>. The amount of intramedullary implanted BMSCs was of 70% at 2\u2009H, 40% at 48\u2009H, and 38% at 168\u2009H. Bone blood flow and bone metabolism were significantly increased during the first week after cell transplantation, but these effects were found to reduce at 2\u2010mo followup. <jats:italic>Conclusion<\/jats:italic>. Short\u2010term cell retention produced concomitant enhancement in irradiated bone blood flow and metabolism.<\/jats:p>","DOI":"10.1155\/2011\/560257","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T19:20:54Z","timestamp":1314645654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem 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