{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:55:17Z","timestamp":1756385717100},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. We report a rare presentation of Castleman's disease in a hepatitis C-positive patient and present a short review of treatments described in other similar case reports and studies.<jats:italic>Case Presentation<\/jats:italic>. A 46-year-old male with untreated hepatitis C and a 16-year history of intravenous drug use presented with pleuritic chest pain and bony pain in the knee, hip, and lower back, on a background of unexplained weight loss of 40 kilograms, fevers, night sweats, and repeated infections over the last two years. Examination discovered tender hepatomegaly, a warm right knee effusion, and painless lymphadenopathy. The patient was reactive to Epstein Barr virus and cytomegalovirus; however, HIV and HHV-8 viral testing was negative. Osteomyelitis of vertebrae T8\u2013T11 and septic arthritis of the knee were found on investigation. A lymph node biopsy revealed histology suggestive of plasmacytic Castleman's disease. The patient is to commence rituximab treatment.<jats:italic>Conclusion<\/jats:italic>. Castleman's disease continues to present in novel ways, which may lead to difficulties in clinicopathologic diagnosis. A growing body of evidence suggests larger studies are required to determine the best treatment for multicentric Castleman's disease, particularly in patients with a concomitant disease, including hepatitis C.<\/jats:p>","DOI":"10.1155\/2011\/567840","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T19:34:31Z","timestamp":1302550471000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report"],"prefix":"10.1155","volume":"2011","author":[{"given":"D. Y.","family":"Talukder","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry, James Cook University, Townsville QLD 4814, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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