{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:10:49Z","timestamp":1792131049433,"version":"4.4.0"},"reference-count":162,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T00:00:00Z","timestamp":1293494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000521","name":"Canadian Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Rodent models of immune\u2010mediated arthritis (RMIA) are the conventional approach to evaluating mechanisms of inflammatory joint disease and the comparative efficacy of antiarthritic agents. Rat adjuvant\u2010induced (AIA), collagen\u2010induced (CIA), and streptococcal cell wall\u2010induced (SCW) arthritides are preferred models of the joint pathology that occurs in human rheumatoid arthritis (RA). Lesions of AIA are most severe and consistent; structural and immunological changes of CIA best resemble RA. Lesion extent and severity in RMIA depends on experimental methodology (inciting agent, adjuvant, etc.) and individual physiologic parameters (age, genetics, hormonal status, etc.). The effectiveness of antiarthritic molecules varies with the agent, therapeutic regimen, and choice of RMIA. All RMIA are driven by overactivity of proinflammatory pathways, but the dominant molecules differ among the models. Hence, as with the human clinical experience, the efficacy of various antiarthritic molecules differs among RMIA, especially when the agent is a specific cytokine inhibitor.<\/jats:p>","DOI":"10.1155\/2011\/569068","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T06:42:27Z","timestamp":1293604947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Rodent Preclinical Models for Developing Novel Antiarthritic Molecules: Comparative Biology and Preferred Methods for Evaluating Efficacy"],"prefix":"10.1155","volume":"2011","author":[{"given":"Brad","family":"Bolon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Stolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Zack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Feige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200006000-00006"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10148"},{"key":"e_1_2_11_3_2","first-page":"1","article-title":"The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and therapeutic consequences","volume":"60","author":"Bl\u00e4ss S.","year":"2001","journal-title":"Zeitschrift f\u00fcr Rheumatologie"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000629"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2001.23704"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02499.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-005-0245-6"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10369"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.suppl_2.ii84"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050601"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111193"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.1.240-249.1986"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1992.tb00833.x"},{"key":"e_1_2_11_14_2","first-page":"602","article-title":"Drug disease interactions: role of inflammatory mediators in disease and variability in drug response","volume":"8","author":"Kulmatycki K. M.","year":"2005","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_11_15_2","volume-title":"Primer on the Rheumatic Diseaes","author":"Klippel J. H.","year":"2001"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076430"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27503"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01978801"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90112-8"},{"key":"e_1_2_11_20_2","first-page":"225","article-title":"Arthritis induced by continuous infusion of hr-interleukin-1\u03b1 into the rabbit knee-joint","volume":"11","author":"Feige U.","year":"1989","journal-title":"International Journal of Tissue Reactions"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.3.314"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1773"},{"key":"e_1_2_11_23_2","first-page":"443","article-title":"The production of arthritis in the guinea-pig by intra-articular reaction between lymphokines and inflammatory leucocytes","volume":"70","author":"Limb G. A.","year":"1989","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899528"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600546"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.05.010"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-999-0011-7"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000060492"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-008-9125-x"},{"key":"e_1_2_11_30_2","volume-title":"The Mouse in Biomedical Research, Vol 4: Immunology","author":"Fox J. G.","year":"2007"},{"key":"e_1_2_11_31_2","unstructured":"IbelgauftsH. COPE (Cytokines & Cells Online Pathfinder Encyclopedia) ed. 24.7 August 2010 http:\/\/www.copewithcytokines.de."},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.5.2916"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.313"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-003-0125-3"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.00243.x"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:32:1-3:005"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/019262339902700125"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.3.495"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.3.857"},{"key":"e_1_2_11_40_2","first-page":"240","article-title":"Collagen-induced arthritis in mice: an animal model to study the pathogenesis of rheumatoid arthritis","volume":"17","author":"Anthony D. D.","year":"1999","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0503"},{"key":"e_1_2_11_42_2","first-page":"197","article-title":"Arthritis induced in rats with adjuvant oil is a genetically restricted, \u03b1\u03b2 T-cell dependent autoimmune disease","volume":"76","author":"Holmdahl R.","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.10.5032"},{"key":"e_1_2_11_44_2","first-page":"38","article-title":"Animal models of chronic inflammatory arthritis","author":"Magilavy D. B.","year":"1990","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_11_45_2","first-page":"565","volume-title":"Arthritis and Allied Conditions","author":"Crofford L. J.","year":"1997"},{"key":"e_1_2_11_46_2","first-page":"311","article-title":"Freund\u2032s adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition","volume":"27","author":"Whitehouse M. W.","year":"1974","journal-title":"Immunology"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1999.00463.x"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.12.6904"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/283666a0"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199106000-00013"},{"key":"e_1_2_11_51_2","first-page":"281","article-title":"Tissue distribution and persistence of arthritogenic and non-arthritogenic Eubacterium cell walls","volume":"17","author":"\u0160imelyte E.","year":"1999","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780050205"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261013"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170508"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150402"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.2.105"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111604"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939508995311"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63542-0"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.01.009"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1522s81"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-3-235"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.10.005"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.12.7324"},{"key":"e_1_2_11_65_2","first-page":"10","article-title":"Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID.bg mice","volume":"21","author":"Sack U.","year":"1994","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00457.x"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.63690130001006"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711340205"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711410406"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02004709"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965007"},{"key":"e_1_2_11_72_2","first-page":"327","article-title":"Inflammation induced by bacterial cell wall fragments in the rat air pouch. Comparison of rat strains and measurement of arachidonic acid metabolites","volume":"121","author":"Yoshino S.","year":"1985","journal-title":"American Journal of Pathology"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb10320.x"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711420107"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22213"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00002-3"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054022141"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80045-X"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00021-7"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.6.2359"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118878"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-4-305"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09789-3_21"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.011"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1981.tb00343.x"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.6.1690"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.129.3.923"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90027-4"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.3.791"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.2.789"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281124"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1080\/13547500802651911"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9238-8"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<2064::AID-ANR18>3.0.CO;2-Z"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290215"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320514"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.6.1585"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8530-7"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198305000-00008"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10546"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-1-30"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21021"},{"key":"e_1_2_11_104_2","first-page":"383","article-title":"The relation of experimental arthritis to the distribution of streptococcal cell wall fragments","volume":"100","author":"Dalldorf F. G.","year":"1980","journal-title":"American Journal of Pathology"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21021"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.3.962"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808172990703"},{"key":"e_1_2_11_108_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.120.4.547"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(83)90106-5"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109136"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320513"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90354-5"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.1.203"},{"key":"e_1_2_11_114_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.1.1"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01257.x"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90019-4"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.5.328"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.11.1077"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00043.x"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00529.x"},{"key":"e_1_2_11_121_2","first-page":"136","article-title":"Articular cartilage changes in early arthritis","volume":"30","author":"Janis R.","year":"1969","journal-title":"Bulletin of the Hospital for Joint Diseases"},{"key":"e_1_2_11_122_2","first-page":"615","article-title":"Antigen retention in joint tissues in antigen induced synovitis","volume":"16","author":"Hollister J. R.","year":"1974","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_11_123_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260910"},{"key":"e_1_2_11_124_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-003-0614-4"},{"key":"e_1_2_11_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0189-9"},{"key":"e_1_2_11_126_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_11_127_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.397"},{"key":"e_1_2_11_128_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00832004"},{"key":"e_1_2_11_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00857.x"},{"key":"e_1_2_11_130_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36389"},{"key":"e_1_2_11_131_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.1.327"},{"key":"e_1_2_11_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380202"},{"key":"e_1_2_11_133_2","first-page":"76","article-title":"Cytokine expression in rheumatoid arthritis","volume":"30","author":"Brennan F. M.","year":"1991","journal-title":"British Journal of Rheumatology"},{"key":"e_1_2_11_134_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011023"},{"key":"e_1_2_11_135_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568010053586372"},{"key":"e_1_2_11_136_2","article-title":"RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNF\u03b1 or anti-IL-1 therapies","volume":"11","author":"Stolina M.","year":"2009","journal-title":"Biomarkers"},{"key":"e_1_2_11_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00832003"},{"key":"e_1_2_11_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.179"},{"key":"e_1_2_11_139_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1444"},{"key":"e_1_2_11_140_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-004-0007-2"},{"key":"e_1_2_11_141_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10173"},{"key":"e_1_2_11_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/1357-4310(96)88772-7"},{"key":"e_1_2_11_143_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408360290795448"},{"key":"e_1_2_11_144_2","first-page":"557","article-title":"Angiogenesis in rheumatoid arthritis","volume":"21","author":"Maruotti N.","year":"2006","journal-title":"Histology and Histopathology"},{"key":"e_1_2_11_145_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05449.x"},{"key":"e_1_2_11_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(96)80017-3"},{"key":"e_1_2_11_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260418"},{"key":"e_1_2_11_148_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2374"},{"key":"e_1_2_11_149_2","doi-asserted-by":"publisher","DOI":"10.1159\/000104855"},{"key":"e_1_2_11_150_2","first-page":"218","article-title":"Abrogation of type II collagen-induced arthritis in rats by psychological stress","volume":"92","author":"Rogers M. P.","year":"1979","journal-title":"Transactions of the Association of American Physicians"},{"key":"e_1_2_11_151_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250647"},{"key":"e_1_2_11_152_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11150"},{"key":"e_1_2_11_153_2","first-page":"42","article-title":"Animal models of rheumatoid arthritis. Clues to etiology and treatment","author":"Brahn E.","year":"1991","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_11_154_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2480"},{"key":"e_1_2_11_155_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10680"},{"key":"e_1_2_11_156_2","doi-asserted-by":"publisher","DOI":"10.1038\/46303"},{"key":"e_1_2_11_157_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1225"},{"key":"e_1_2_11_158_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-008-0855-3"},{"key":"e_1_2_11_159_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4"},{"key":"e_1_2_11_160_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.26.3.791-794.1979"},{"key":"e_1_2_11_161_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1266::AID-ANR9>3.0.CO;2-P"},{"key":"e_1_2_11_162_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.2007"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/569068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/569068.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2011\/569068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T11:06:05Z","timestamp":1720091165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2011\/569068"}},"subtitle":[],"editor":[{"given":"Oreste","family":"Gualillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,28]]},"references-count":162,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1155\/2011\/569068"],"URL":"https:\/\/doi.org\/10.1155\/2011\/569068","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,28]]},"assertion":[{"value":"2010-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"569068"}}