{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:29:37Z","timestamp":1773239377961,"version":"3.50.1"},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Shanghai Shen Kang Hospital Management Center","award":["SHDC12010111"],"award-info":[{"award-number":["SHDC12010111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Empirical therapy with antisecretory agents like PPIs and H2RAs has long been the traditional approach in the initial management of uninvestigated dyspepsia.<jats:italic>Aim<\/jats:italic>. The objective of the study was to examine relief of dyspepsia with lafutidine, a second-generation<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>H<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>-RA, and rabeprazole and to compare their efficacy.<jats:italic>Methods<\/jats:italic>. This was a randomized, open, comparative trial in adult uninvestigated dyspeptic patients, who had at least moderate severity of symptoms, defined as a score of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u2265<\/mml:mo><\/mml:math>4 on a 7-point global overall symptom (GOS) scale, and were randomized to receive once daily either lafutidine 10\u2009mg or rabeprazole 20\u2009mg for 4 weeks.<jats:italic>Results<\/jats:italic>. A total of 236 patients were enrolled, out of which 194 patients were included in the analysis. At the end of week 4, a significant difference was observed for symptom relief (lafutidine 89.90% versus rabeprazole 65.26%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>) and symptom resolution (lafutidine 70.71% versus rabeprazole 25.26%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>). Both the drugs were well tolerated.<jats:italic>Conclusion<\/jats:italic>. Both lafutidine and rabeprazole provide symptom relief in patients with heartburn-dominant uninvestigated dyspepsia. The present study confirms the appropriateness of lafutidine as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia.<\/jats:p>","DOI":"10.1155\/2011\/640685","type":"journal-article","created":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T19:33:04Z","timestamp":1304623984000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial"],"prefix":"10.1155","volume":"2011","author":[{"given":"Bhupesh","family":"Dewan","sequence":"first","affiliation":[{"name":"Medical Services Department, Zuventus Healthcare Ltd, 5119 \u201cD\u201d Wing, Oberoi Garden Estate, Chandivilli, Mumbai 400072, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Philipose","sequence":"additional","affiliation":[{"name":"Clinical Research Associate, Medical Services 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