{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:27:00Z","timestamp":1777998420495,"version":"3.51.4"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Topical treatment of cutaneous leishmaniasis is an attractive alternative avoiding toxicities of parenteral therapy while being administered through a simple painless route. Recently liposomal formulations of amphotericin B have been increasingly used in the treatment of several types of leishmaniasis.<jats:italic>Aims<\/jats:italic>. The efficacy of a topical liposomal amphotericin B formulation was compared with intralesional glucantime in the treatment of cutaneous leishmaniasis.<jats:italic>Methods<\/jats:italic>. From 110 patients, the randomly selected 50 received a topical liposomal formulation of amphotericin B into each lesion, 3\u20137 drops twice daily, according to the lesion's size and for 8 weeks. The other group of 60 patients received intralesional glucantime injection of 1-2\u2009mL once a week for the same period. The clinical responses and side effects of both groups were evaluated weekly during the treatment course.<jats:italic>Results<\/jats:italic>. Per-protocol analysis showed no statistically significant difference between the two groups (, 95% confidence interval (0.632\u20134.101)). Moreover, after intention-to-treat analysis, the same results were seen (, 95% (0.560\u20132.530)). Serious post treatment side effects were not observed in either group.<jats:italic>Conclusions<\/jats:italic>. Topical liposomal amphotericin B has the same efficacy as intralesional glucantime in the treatment of cutaneous leishmaniasis.<\/jats:p>","DOI":"10.1155\/2011\/656523","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T16:02:09Z","timestamp":1322150529000},"page":"1-5","source":"Crossref","is-referenced-by-count":41,"title":["Efficacy of Topical Liposomal Amphotericin B versus Intralesional Meglumine Antimoniate (Glucantime) in the Treatment of Cutaneous Leishmaniasis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Pouran","family":"Layegh","sequence":"first","affiliation":[{"name":"Research Center for Skin Diseases & Cutaneous Leishmaniasis, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Reza","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Emamgholi Tabar Malekshah","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toktam","family":"Moghiman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hami","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshanak","family":"Salari","sequence":"additional","affiliation":[{"name":"Buali (Avicenna) Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00664.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02182.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3274-3280.2005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/1381612023396258"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4269\/ajtmh.1995.52.536","volume":"52","year":"1995","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"issue":"2","key":"6","first-page":"144","volume":"66","year":"2002","journal-title":"American Journal of Tropical Medicine and 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