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The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral<jats:italic>streptococci<\/jats:italic>mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues.<jats:italic>Bes-1<\/jats:italic>gene encoded partial<jats:italic>S. sanguinis<\/jats:italic>genome which is highly homologous with retinal protein, and 65\u2009kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65\/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.<\/jats:p>","DOI":"10.1155\/2011\/681956","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T19:33:19Z","timestamp":1288639999000},"page":"1-7","source":"Crossref","is-referenced-by-count":37,"title":["Beh\u00e7et's Disease (Adamantiades-Beh\u00e7et's Disease)"],"prefix":"10.1155","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-889X","authenticated-orcid":true,"given":"Fumio","family":"Kaneko","sequence":"first","affiliation":[{"name":"Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Togashi","sequence":"additional","affiliation":[{"name":"Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research 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