{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:18:32Z","timestamp":1782836312469,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LSHP-CT-2003-503240"],"award-info":[{"award-number":["LSHP-CT-2003-503240"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>The<jats:italic>M. tuberculosis<\/jats:italic>phosphate-binding transporter lipoproteins PstS1 and PstS3 were good immunogens inducing CD8<jats:sup>+<\/jats:sup>T-cell activation and both Th1 and Th17 immunity in mice. However, this antigen-specific immunity, even when amplified by administration of the protein with the adjuvant LTK63 or by the DNA priming\/protein boosting regimen, was not able to contain<jats:italic>M. tuberculosis<\/jats:italic>replication in the lungs of infected mice. The lack of protection might be ascribed with the scarce\/absent capacity of PstS1\/PstS3 antigens to modulate the IFN-\u03b3 response elicited by<jats:italic>M. tuberculosis<\/jats:italic>infection during which, however, PstS1-specific IL-17 secreting cells were generated in both unvaccinated and BCG-vaccinated mice. In spite of a lack of protection by PstS1\/PstS3 immunizations, our results do show that PstS1 is able to induce IL-17 response upon<jats:italic>M. tuberculosis<\/jats:italic>infection which is of interest in the study of anti-<jats:italic>M. tuberculosis<\/jats:italic>immunity and as potential immunomodulator in combined vaccines.<\/jats:p>","DOI":"10.1155\/2011\/690328","type":"journal-article","created":{"date-parts":[[2011,3,27]],"date-time":"2011-03-27T19:32:22Z","timestamp":1301254342000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["The<i>M. tuberculosis<\/i>Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against<i>M. tuberculosis<\/i>Infection"],"prefix":"10.1155","volume":"2011","author":[{"given":"Carla","family":"Palma","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 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