{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:19:59Z","timestamp":1791206399329,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2011]]},"abstract":"\n IFN-\n \u03b3<\/jats:italic>\n has been used in the treatment of IL-12R\n \u03b2<\/jats:italic>\n 1 deficiency patients with disseminated BCG infection (BCGosis), but the optimal dose to reach efficacy is not clear. We used IFN-\n \u03b3<\/jats:italic>\n in the treatment of a 2.7-year-old patient with IL-12R\n \u03b2<\/jats:italic>\n 1 deficiency and refractory BCG-osis. IFN\n \u03b3<\/jats:italic>\n was started at a dose of 50\u2009\n \u03bc<\/jats:italic>\n g\/m\n 2<\/jats:sup>\n 3 times per week. The dose was upgraded to 100\u2009mcg\/m\n 2<\/jats:sup>\n after 3 months, then to 200\u2009mcg\/m\n 2<\/jats:sup>\n 6 months afterwards. Serum mycobactericidal activity and lymphocytes number and function were evaluated throughout the study. There was no clinical response to IFN-\n \u03b3<\/jats:italic>\n with 50 or 100\u2009\n \u03bc<\/jats:italic>\n g\/m\n 2<\/jats:sup>\n doses. However, there was some response to the 200\u2009\n \u03bc<\/jats:italic>\n g\/m\n 2<\/jats:sup>\n dose with no additional adverse effects. The serum mycobactericidal activity was not significantly different during the whole treatment period. Lymphocytes proliferation in response to PHA was significantly higher after 3 months of using the highest dose as compared to the lowest dose. The tuberculin skin test reaction remained persistently negative. We conclude that in a patient with IL-12R\n \u03b2<\/jats:italic>\n 1 deficiency, IFN-\n \u03b3<\/jats:italic>\n at a dose of 200\u2009\n \u03bc<\/jats:italic>\n g\/m\n 2<\/jats:sup>\n , but not at lower dosages, was found to have a noticeable clinical effect with no additional adverse effects.\n <\/jats:p>","DOI":"10.1155\/2011\/691956","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T17:35:00Z","timestamp":1293039300000},"page":"1-5","source":"Crossref","is-referenced-by-count":56,"title":["Treatment of Disseminated Mycobacterial Infection with High-Dose IFN-\n \u03b3<\/i>\n in a Patient with IL-12R\n \u03b2<\/i>\n 1 Deficiency"],"prefix":"10.1155","volume":"2011","author":[{"given":"Abdullah A.","family":"Alangari","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al-Zamil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Al-Mazrou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Al-Muhsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Boisson-Dupuis","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm, U550, 75654 Paris, France"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, St. Giles, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitalbanat","family":"Awadallah","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmageed","family":"Kambal","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm, U550, 75654 Paris, France"},{"name":"Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, St. Giles, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.081501.125851"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.07.010"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.037"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1432"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021769"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526258"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181fdd832"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301904"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.07.009"},{"issue":"8","key":"10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJM199102213240801","volume":"324","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1599-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000552"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01051.x"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/691956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/691956.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/691956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T13:34:54Z","timestamp":1497879294000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2011\/691956\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":13,"alternative-id":["691956","691956"],"URL":"https:\/\/doi.org\/10.1155\/2011\/691956","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"value":"1740-2522","type":"print"},{"value":"1740-2530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}