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Male Wistar rats were treated with carbon tetrachloride (0.4\u2009g\/kg body weight) intraperitoneally daily for 8 weeks. Resveratrol (100\u2009mg\/kg, 200\u2009mg\/kg body weight) was given orally from first day until the last day of experiment. The investigation assesses the effect of resveratrol on morphological, oxidative status, histopathological, immunohistochemical, and apoptotic analysis in carbon tetrachloride-challenged liver tissue. The study indicated that the inflammatory cytokines TNF-<jats:italic>\u03b1<\/jats:italic>and IL-6 were profoundly expressed in experimental rats, whereas resveratrol decreases the immunopositivity of TNF-<jats:italic>\u03b1<\/jats:italic>and IL-6 and restored the altered architectural structure of challenged hepatic tissue. Resveratrol also protects liver cells by suppressing oxidative stress and apoptosis.<\/jats:p>","DOI":"10.1155\/2011\/703676","type":"journal-article","created":{"date-parts":[[2011,10,16]],"date-time":"2011-10-16T07:18:19Z","timestamp":1318749499000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury"],"prefix":"10.1155","volume":"2011","author":[{"given":"Souvik","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. Saha Road, Kolkata 700053, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Sannigrahi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, NSHM Knowledge Campus, 124 B.L. 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