{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:42:06Z","timestamp":1783449726736,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T00:00:00Z","timestamp":1294012800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. To establish a new model of zymosan\u2010induced temporomandibular joint (TMJ) arthritis in the rat and to investigate the role of nitric oxide.<jats:italic>Methods<\/jats:italic>. Inflammation was induced by an intra\u2010articular injection of zymosan into the left TMJ. Mechanical hypernociception, cell influx, vascular permeability, myeloperoxidase activity, nitrite levels, and histological changes were measured in TMJ lavages or tissues at selected time points. These parameters were also evaluated after treatment with the nitric oxide synthase (NOS) inhibitors L\u2010NAME or 1400\u2009W.<jats:italic>Results<\/jats:italic>. Zymosan\u2010induced TMJ arthritis caused a time\u2010dependent leucocyte migration, plasma extravasation, mechanical hypernociception, and neutrophil accumulation between 4 and 24\u2009h. TMJ immunohistochemical analyses showed increased inducible NOS expression. Treatment with L\u2010NAME or 1400\u2009W inhibited these parameters.<jats:italic>Conclusion<\/jats:italic>. Zymosan\u2010induced TMJ arthritis is a reproducible model that may be used to assess both the mechanisms underlying TMJ inflammation and the potential tools for therapies. Nitric oxide may participate in the inflammatory temporomandibular dysfunction mechanisms.<\/jats:p>","DOI":"10.1155\/2011\/707985","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T19:40:33Z","timestamp":1294083633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Experimental Model of Zymosan\u2010Induced Arthritis in the Rat Temporomandibular Joint: Role of Nitric Oxide and Neutrophils"],"prefix":"10.1155","volume":"2011","author":[{"given":"Hell\u00edada Vasconcelos","family":"Chaves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo de Albuquerque","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Mattos Brito","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Alfredo Rodrigues e","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniella Souza","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Lima","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna Marques","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerly Anne de Castro","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,3]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02074.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(88)90008-8"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90026-5"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00104-M"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00309-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00027-1"},{"key":"e_1_2_7_7_2","first-page":"9","article-title":"A model for the study of experimentally induced temporomandibular arthritis in rats: the effect of human recombinant interleukin-1\u03b1 on neuropeptide-like immunoreactivity","volume":"10","author":"Carleson J.","year":"1996","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790071001"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(98)00095-8"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02037.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(99)00136-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790091101"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00357-8"},{"key":"e_1_2_7_14_2","first-page":"2","article-title":"Capsaicin-induced joint inflammation is not blocked by local anesthesia","volume":"51","author":"Tang M. 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