{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T20:04:48Z","timestamp":1773518688144,"version":"3.50.1"},"reference-count":136,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Despite continuous progress in our understanding of the pathogenesis of congestive heart failure (CHF) and its management, mortality remains high. Therefore, development of reliable experimental models of CHF and cardiac hypertrophy is essential to better understand disease progression and allow new therapy developement. The aortocaval fistula (ACF) model, first described in dogs almost a century ago, has been adopted in rodents by several groups including ours. Although considered to be a model of high\u2010output heart failure, its long\u2010term renal and cardiac manifestations are similar to those seen in patients with low\u2010output CHF. These include Na<jats:sup>+<\/jats:sup>\u2010retention, cardiac hypertrophy and increased activity of both vasoconstrictor\/antinatriureticneurohormonal systems and compensatory vasodilating\/natriuretic systems. Previous data from our group and others suggest that progression of cardiorenal pathophysiology in this model is largely determined by balance between opposing hormonal forces, as reflected in states of CHF decompensation that are characterized by overactivation of vasoconstrictive\/Na<jats:sup>+<\/jats:sup>\u2010retaining systems. Thus, ACF serves as a simple, cheap, and reproducible platform to investigate the pathogenesis of CHF and to examine efficacy of new therapeutic approaches. Hereby, we will focus on the neurohormonal, renal, and cardiac manifestations of the ACF model in rats, with special emphasis on our own experience.<\/jats:p>","DOI":"10.1155\/2011\/729497","type":"journal-article","created":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T21:33:56Z","timestamp":1294781636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Aortocaval Fistula in Rat: A Unique Model of Volume\u2010Overload Congestive Heart Failure and Cardiac Hypertrophy"],"prefix":"10.1155","volume":"2011","author":[{"given":"Zaid","family":"Abassi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Goltsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Karram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Winaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-999-0035-7"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021498"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00110-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1973.122"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180337"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.7.597"},{"key":"e_1_2_7_7_2","first-page":"R776","article-title":"Hormonal determinants of sodium excretion in rats with experimental high-output heart failure","volume":"254","author":"Winaver J.","year":"1988","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_8_2","first-page":"R84","article-title":"Effect of converting-enzyme inhibition on renal response to ANF in rats with experimental heart failure","volume":"259","author":"Abassi Z.","year":"1990","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01186.2004"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00245-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3655"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.4.746"},{"key":"e_1_2_7_13_2","first-page":"247","article-title":"Does the heart\u2032s hormone, ANP, help in congestive heart failure?","volume":"10","author":"Winaver J.","year":"1995","journal-title":"News in Physiological Sciences"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/08941930500328839"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/24.5.430"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2907"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS103S245S"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103126"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108780"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.220.4.952"},{"key":"e_1_2_7_21_2","first-page":"H942","article-title":"Effects of indomethacin in conscious dogs with experimental high-output heart failure","volume":"245","author":"Villarreal D.","year":"1983","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_7_22_2","first-page":"H739","article-title":"DOCA administration and atrial natriuretic factor in dogs with chronic heart failure","volume":"257","author":"Villarreal D.","year":"1989","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_23_2","first-page":"R509","article-title":"Captopril enhances renal responsiveness to ANF in dogs with compensated high-output heart failure","volume":"262","author":"Villarreal D.","year":"1992","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_24_2","first-page":"H1187","article-title":"Neurohumoral modulators and sodium balance in experimental heart failure","volume":"264","author":"Villarreal D.","year":"1993","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193518940-00004"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102732"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102770"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00647458"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.1.52"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108431"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.10.3105"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.3.921"},{"key":"e_1_2_7_33_2","first-page":"515","article-title":"ANF and the renin-angiotensin system in the regulation of sodium balance: longitudinal studies in experimental heart failure","volume":"118","author":"Villarreal D.","year":"1991","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_7_34_2","first-page":"66","article-title":"Adaptive and maladaptive actions of angiotensin II in patients with severe congestive heart failure","volume":"10","author":"Packer M.","year":"1987","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01410210"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.156"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0022-3565(25)38470-3","article-title":"Losartan improves the natriuretic response to ANF in rats with high- output heart failure","volume":"268","author":"Abassi Z. A.","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00335-6"},{"key":"e_1_2_7_39_2","first-page":"398","volume-title":"The Kidney","author":"Skorecki K. L.","year":"2008"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01907376"},{"key":"e_1_2_7_41_2","first-page":"R1599","article-title":"Effects of renal denervation on postprandial sodium excretion in experimental heart failure","volume":"266","author":"Villarreal D.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_42_2","first-page":"S20","article-title":"Physiology of ADH secretion","volume":"32","author":"Robertson G. L.","year":"1987","journal-title":"Kidney International"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00328-5"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.137745"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80040-0"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.095"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191705"},{"key":"e_1_2_7_48_2","first-page":"S57","article-title":"Sodium and water retention in heart failure: pathogenesis and treatment","volume":"51","author":"Martin P. Y.","year":"1997","journal-title":"Kidney International, Supplement"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1963"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.001315"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000186852.15889.1a"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330607"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0215"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199401000-00010"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00055-7"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.4.1374"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.03.016"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)88611-1"},{"key":"e_1_2_7_59_2","first-page":"F312","article-title":"Endothelin in experimental congestive heart failure in the anesthetized dog","volume":"259","author":"Cavero P. G.","year":"1990","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.13.6.643"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90468-G"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.49"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.6.508"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V103572"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2935937"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.2.398"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114385"},{"key":"e_1_2_7_68_2","first-page":"F119","article-title":"Regulation of renal glomerular and papillary ANP receptors in rats with experimental heart failure","volume":"265","author":"Yechieli H.","year":"1993","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_69_2","first-page":"R858","article-title":"Atrial natriuretic peptide and renal cGMP in rats with experimental heart failure","volume":"261","author":"Abassi Z.","year":"1991","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.253.1.C147"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4001.097191"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00737.2004"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.16.6465"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2002.00288.x"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020161"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.20.2.273"},{"key":"e_1_2_7_77_2","first-page":"S123","article-title":"Role of angiotensin II in altered glomerular hemodynamics in congestive heart failure","volume":"38","author":"Ichikawa I.","year":"1990","journal-title":"Kidney International"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90183-N"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199800001-00011"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.4.F766"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000166302.56184.fa"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000166214.42791.f2"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16723-8"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_2_7_85_2","first-page":"F43","article-title":"Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure","volume":"280","author":"Abassi Z.","year":"2001","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.1.308"},{"key":"e_1_2_7_87_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01647.x"},{"key":"e_1_2_7_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.149"},{"key":"e_1_2_7_89_2","first-page":"H2245","article-title":"Effects of oral AVP receptor antagonists OPC-21268 and OPC-31260 on congestive heart failure in conscious dogs","volume":"267","author":"Naitoh M.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0290001"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119312"},{"key":"e_1_2_7_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.276"},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00297-8"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070422.41439.04"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50021"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)94708-3"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200110000-00026"},{"key":"e_1_2_7_98_2","first-page":"3824","article-title":"Transition from hypertrophy to failure","volume":"96","author":"Lorell B. H.","year":"1997","journal-title":"Circulation"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.5.1167"},{"key":"e_1_2_7_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb33529.x"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01931494"},{"key":"e_1_2_7_102_2","first-page":"47","article-title":"Cardiac hypertrophy induced by \u03b1- and \u03b2-adrenergic receptor stimulation","volume":"6","author":"Zimmer H. G.","year":"1995","journal-title":"Cardioscience"},{"key":"e_1_2_7_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.1.116"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199506000-00017"},{"key":"e_1_2_7_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80043-4"},{"key":"e_1_2_7_106_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200007000-00007"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-389-3_27"},{"key":"e_1_2_7_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.04.002"},{"key":"e_1_2_7_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761"},{"key":"e_1_2_7_110_2","first-page":"H698","article-title":"Chronic arteriovenous shunt: evaluation of a model for heart failure in rat","volume":"236","author":"Flaim S. F.","year":"1979","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_7_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.2385"},{"key":"e_1_2_7_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68074-4"},{"key":"e_1_2_7_113_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2002.129250"},{"key":"e_1_2_7_114_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03086131"},{"key":"e_1_2_7_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9164(96)80010-8"},{"key":"e_1_2_7_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"e_1_2_7_117_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0934"},{"key":"e_1_2_7_118_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003920050001"},{"key":"e_1_2_7_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90167-L"},{"key":"e_1_2_7_120_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2003.tb00197.x"},{"key":"e_1_2_7_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039104.56479.42"},{"key":"e_1_2_7_122_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.2.H647"},{"key":"e_1_2_7_123_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608283150901"},{"key":"e_1_2_7_124_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112154"},{"key":"e_1_2_7_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80086-9"},{"key":"e_1_2_7_126_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.113215"},{"key":"e_1_2_7_127_2","doi-asserted-by":"publisher","DOI":"10.1111\/paa.1999.111.5.406"},{"key":"e_1_2_7_128_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104901012"},{"key":"e_1_2_7_129_2","first-page":"H2071","article-title":"Temporal evaluation of left ventricular remodeling and function in rats with chronic volume overload","volume":"271","author":"Brower G. L.","year":"1996","journal-title":"American Journal of Physiology"},{"key":"e_1_2_7_130_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.3.H846"},{"key":"e_1_2_7_131_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.2.H674"},{"key":"e_1_2_7_132_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00248.2002"},{"key":"e_1_2_7_133_2","first-page":"89","article-title":"Factors determining electrolyte excretion and renin secretion after closure of an arteriovenous fistula in the dog","volume":"98","author":"Humphreys M. H.","year":"1981","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_7_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90440-O"},{"key":"e_1_2_7_135_2","first-page":"1","article-title":"Aorta-vena cava fistula","volume":"105","author":"Alexander J. J.","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_7_136_2","first-page":"H555","article-title":"Changes in the sensitivity of left atrial receptors following reversal of heart failure","volume":"237","author":"Zucker I. H.","year":"1979","journal-title":"The American Journal of Physiology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/729497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/729497.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2011\/729497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T16:41:34Z","timestamp":1740847294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2011\/729497"}},"subtitle":[],"editor":[{"given":"Oreste","family":"Gualillo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1155\/2011\/729497"],"URL":"https:\/\/doi.org\/10.1155\/2011\/729497","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2010-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"729497"}}