{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:06:01Z","timestamp":1789909561661,"version":"4.0.1"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate if new imiquimod formulations using a shorter treatment duration are safe and efficacious to treat anogenital warts.<jats:italic>Methods<\/jats:italic>. In two studies 534 women \u226512 years of age (mean 33.4) with 2\u201330 warts (mean 7.9) and total wart area<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>\u2265<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mm<jats:sup>2<\/jats:sup>(mean 166.3) were randomized (1\u2009:\u20092\u2009:\u20092) to placebo (106), imiquimod 2.5% (212) or 3.75% (216) creams applied once daily until complete clearance or a maximum of 8 weeks.<jats:italic>Results<\/jats:italic>. For placebo, imiquimod 2.5% and 3.75%, respectively, complete clearance of all warts was achieved in 14.2%, 28.3%, and 36.6% of women (intent-to-treat,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:mrow><\/mml:math>imiquimod 2.5%, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>3.75% versus placebo). Mean changes in wart counts were \u221210.7%, \u221250.9%, and \u221263.5% (per-protocol,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>each active versus placebo) and safety-related discontinuation rates 0.9%, 1.4%, and 2.3%.<jats:italic>Conclusions<\/jats:italic>. Imiquimod 3.75% applied daily for up to 8 weeks was well tolerated and superior to placebo in treating women with external anogenital warts.<\/jats:p>","DOI":"10.1155\/2011\/806105","type":"journal-article","created":{"date-parts":[[2011,8,26]],"date-time":"2011-08-26T14:59:00Z","timestamp":1314370740000},"page":"1-11","source":"Crossref","is-referenced-by-count":33,"title":["Imiquimod 3.75% Cream Applied Daily to Treat Anogenital Warts: Combined Results from Women in Two Randomized, Placebo-Controlled Studies"],"prefix":"10.1155","volume":"2011","author":[{"given":"David A.","family":"Baker","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Obstetrics, Gynecology & Reproductive Medicine, Stony Brook Health Science Center, Stony Brook University Medical Center, Stony Brook, NY 11794-8091, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daron G.","family":"Ferris","sequence":"additional","affiliation":[{"name":"Departments of 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