{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:39:04Z","timestamp":1790905144687,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T00:00:00Z","timestamp":1303776000000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["0427657"],"award-info":[{"award-number":["0427657"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Chemotherapeutic agents for cancer are highly toxic to healthy tissues and hence alternative medicine avenues are widely researched.  Majority of the recent studies on alternative medicine suggested that <jats:italic>Amoora rohituka<\/jats:italic> possesses considerable antitumor and antibacterial properties.  In this work, <jats:italic>rohituka<\/jats:italic> and <jats:italic>chittagonga<\/jats:italic>, fractionated with petroleum ether, dichloromethane, and ethanol, were explored for their anticancer potential against two breast cancer (MCF\u20107 and HTB\u2010126) and three pancreatic cancer (Panc\u20101, Mia\u2010Paca2, and Capan1).  The human foreskin fibroblast, Hs68, was also included.  Cytotoxicity of each extract was analyzed using the MTT assay and label\u2010free photonic crystal biosensor assay.  A concentration series of each extract was performed on the six cell lines.  For MCF\u20107 cancer cells, the <jats:italic>chittagonga<\/jats:italic> (Pet\u2010Ether and CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub>) and <jats:italic>rohituka<\/jats:italic> (Pet\u2010Ether) extracts induced cytotoxicity; the <jats:italic>chittagonga<\/jats:italic> (EtoAC) and <jats:italic>rohituka<\/jats:italic> (MeOH) extracts did not induce cytotoxicity.  For HTB126, Panc\u20101, Mia\u2010Paca2, and Capan\u20101 cancer cells, only the <jats:italic>chittagonga<\/jats:italic>  CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> extract showed a significant cytotoxic effect.  The extracts were not cytotoxic to normal fibroblast Hs68 cells, which may be correlated to the specificity of <jats:italic>Amoora<\/jats:italic> extracts in targeting cancerous cells.  Based on these results, further examination of the potential anticancer properties <jats:italic>Amoora<\/jats:italic> species and the identification of the active ingredients of these extracts is warranted.<\/jats:p>","DOI":"10.1155\/2011\/860605","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T19:32:13Z","timestamp":1303846333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cytotoxicity Effects of <i>Amoora rohituka<\/i> and <i>chittagonga<\/i> on Breast and Pancreatic Cancer Cells"],"prefix":"10.1155","volume":"2011","author":[{"given":"Leo L.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saujanya L.","family":"Gosangari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiya","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Watkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24760"},{"key":"e_1_2_8_2_2","volume-title":"American Cancer Society","year":"2009"},{"key":"e_1_2_8_3_2","volume-title":"National Cancer Institute","year":"2007"},{"key":"e_1_2_8_4_2","volume-title":"National Cancer Institute, U.S. National Institutes of Health","year":"2009"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1300\/J077v21n02_01"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/13880209509065396","article-title":"Antitumor and cytotoxic investigation of Amoora rohituka","volume":"33","author":"Rabi T.","year":"1995","journal-title":"International Journal of Pharmacognosy"},{"key":"e_1_2_8_7_2","first-page":"80","article-title":"Antitumour activity of amooranin from Amoora rohituka stem bark","volume":"70","author":"Rabi T.","year":"1996","journal-title":"Current Science"},{"key":"e_1_2_8_8_2","volume-title":"Indian Medicinal Plants","author":"Kirtikar K. 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