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On the one side, p63 is required to sustain the proliferation of keratinocyte progenitors, while on the other side it is required for cell stratification, commitment to differentiate, cell adhesion, and epithelial\u2010mesenchymal signaling.  Molecules that are components or regulators of the p63 pathway(s) are rapidly being identified, and it comes with no surprise that alterations in the p63 pathway lead to congenital conditions in which the skin and other ectoderm\u2010derived structures are affected. In this paper, we summarize the current knowledge of the molecular and cellular regulations centered on p63, derived from the comprehension of p63\u2010linked human diseases and the corresponding animal models, as well as from cellular models and high\u2010throughput molecular approaches.  We point out common themes and features, that allow to speculate on the possible role of p63 downstream events and their potential exploitation in future attempts to correct the congenital defect in preclinical studies.<\/jats:p>","DOI":"10.1155\/2011\/864904","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T19:34:15Z","timestamp":1306092855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Symphony of Regulations Centered on <i>p63<\/i> to Control Development of Ectoderm\u2010Derived Structures"],"prefix":"10.1155","volume":"2011","author":[{"given":"Luisa","family":"Guerrini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio 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