{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:55:49Z","timestamp":1761947749144},"reference-count":57,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Alabama A&M University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. Soybean is a rich source of phytonutrients such as isoflavones. The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis. After one wk of acclimatization, Fisher 344 male rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>90<\/mml:mn><\/mml:mrow><\/mml:math>) were randomly assigned to 9 groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>). Control rats (C) were fed AIN-93G\/M. Two s\/c injections of AOM were administered to rats at 7 and 8\u2009wk of age at 16\u2009mg\/kg body weight. Rats were killed by CO<jats:sub>2<\/jats:sub>asphyxiation at 45\u2009wk. Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C. Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development.<\/jats:p>","DOI":"10.1155\/2011\/868197","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T19:23:08Z","timestamp":1317064988000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Combinational Effects of Prebiotics and Soybean against Azoxymethane-Induced Colon Cancer<i>In Vivo<\/i>"],"prefix":"10.1155","volume":"2011","author":[{"given":"V. 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