{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T22:27:00Z","timestamp":1648765620028},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or S\u00e9zary syndrome (SS). In MF\/SS, the LNs may have a pathologic diagnosis of either dermatopathic lymphadenopathy (LN-DL) or involvement by MF\/SS (LN-MF). We performed immunohistochemical staining on MF\/SS lymph nodes using antibodies to thymidine phosphorylase, CD68, CD21, CD3, and CD4. In both LN-DL and benign nodes, thymidine phosphorylase staining was noted only in macrophages, dendritic cells, and endothelial cells. In LN-MF, thymidine phosphorylase expression was also noted in subsets of intermediate to large neoplastic T cells. Concurrent CD68, CD21, CD3, and CD4 staining supported the above observations. Similar results were noted in the skin and in LN-MF with large cell transformation. Other T-cell lymphomas were also examined (total 7 cases); only enteropathy-type T-cell lymphoma (1 case) showed TP positivity in neoplastic T lymphocytes. We demonstrated that thymidine phosphorylase staining is present in neoplastic T cells in mycosis fungoides. The exact mechanism needs further investigation.<\/jats:p>","DOI":"10.1155\/2011\/875135","type":"journal-article","created":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T14:02:22Z","timestamp":1321279342000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and S\u00e9zary Syndrome"],"prefix":"10.1155","volume":"2011","author":[{"given":"Xingcao","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Pathology, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 435, Philadelphia, PA 19102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 435, Philadelphia, PA 19102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essel Dulaimi","family":"Al-Saleem","sequence":"additional","affiliation":[{"name":"Department of Pathology, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 435, Philadelphia, PA 19102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Vonderheid","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medical Institutes, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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