{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T18:22:13Z","timestamp":1747074133143,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. To analyze patients with atypical squamous cells of undetermined significance (ASCUS) through a cytology review and the presence of microbiological agents, with consideration of colposcopy and semiannual tracking.<jats:italic>Methods<\/jats:italic>. 103 women with ASCUS were reviewed and reclassified: normal\/inflammatory, ASCUS, low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL). If ASCUS confirmed, it was subclassified in reactive or neoplastic ASCUS, ASC-US, or ASC-H; and Regione Emilia Romagna Screening Protocol. Patients underwent a colposcopic examination, and test for<jats:italic>Candida<\/jats:italic>sp., bacterial vaginosis,<jats:italic>Trichomonas vaginalis<\/jats:italic>, and human papillomavirus (HPV) were performed.<jats:italic>Results<\/jats:italic>. Upon review, ASCUS was diagnosis in 70\/103 (67.9%), being 38 (54.2%) reactive ASCUS and 32 (45.71%) neoplastic ASCUS; 62 (88.5%) ASC-US and 8 (11.41%) ASC-H. ASCUS (Regione Protocol), respectively 1-5: 15 (21.4%), 19 (27.1%), 3 (27.1%), 16 (22.8%), and 1 (1.4%). A higher number of cases of cervical intraepithelial neoplasia (CIN) II\/III in the biopsies of patients with ASC-H compared to ASC-US (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.0021<\/mml:mn><\/mml:mrow><\/mml:math>). High-risk HPV test and presence of CIN II\/III are more frequent in ASC-H than ASC-US (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.031<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. ASC-H is associated with clinically significant disease. High-risk HPV-positive status in the triage for colposcopy of patients with ASC-US is associated with increased of CIN.<\/jats:p>","DOI":"10.1155\/2011\/904674","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T21:42:23Z","timestamp":1309383743000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ana Cristina Mac\u00eado","family":"Barcelos","sequence":"first","affiliation":[{"name":"Discipline of Gynecology and Obstetrics, Oncology Research Institute (IPON), UFTM, 38025-440 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Antoniazi","family":"Michelin","sequence":"additional","affiliation":[{"name":"Discipline of Special Pathology, UFTM, 38025-440 Uberaba, MG, 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