{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:47:55Z","timestamp":1790542075162,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["S2011-2"],"award-info":[{"award-number":["S2011-2"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","award":["S2011-2"],"award-info":[{"award-number":["S2011-2"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004043","name":"Kanazawa Medical University","doi-asserted-by":"publisher","award":["S2011-2"],"award-info":[{"award-number":["S2011-2"]}],"id":[{"id":"10.13039\/501100004043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Diabetes Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (<jats:italic>fa\/fa<\/jats:italic>) rats (WFRs).<jats:italic>Methods<\/jats:italic>. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-<jats:italic>\u03ba<\/jats:italic>B (p65), Sirt1 protein expression, and p62\/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated.<jats:italic>Results<\/jats:italic>. DR ameliorated renal abnormalities including inflammation in WFRs. The decrease in Sirt1 levels, increase in acetylated-NF-<jats:italic>\u03ba<\/jats:italic>B, and impaired autophagy in WFRs were improved by DR.<jats:italic>Conclusions<\/jats:italic>. DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.<\/jats:p>","DOI":"10.1155\/2011\/908185","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T15:07:26Z","timestamp":1316704046000},"page":"1-11","source":"Crossref","is-referenced-by-count":188,"title":["Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (<i>fa\/fa<\/i>) Rats: A Model of Type 2 Diabetes"],"prefix":"10.1155","volume":"2011","author":[{"given":"Munehiro","family":"Kitada","sequence":"first","affiliation":[{"name":"Division of Diabetes & Endocrinology, Kanazawa Medical University, Kahoku-Gun, Ishikawa Prefecture 920-0293, 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