{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:10:23Z","timestamp":1790525423598,"version":"4.1.0"},"reference-count":117,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI072021-03"],"award-info":[{"award-number":["R01 AI072021-03"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>The protozoan parasite<jats:italic>Entamoeba histolytica<\/jats:italic>is responsible for invasive intestinal and extraintestinal amebiasis. The virulence of<jats:italic>Entamoeba histolytica<\/jats:italic>is strongly correlated with the parasite's capacity to effectively kill and phagocytose host cells. The process by which host cells are killed and phagocytosed follows a sequential model of adherence, cell killing, initiation of phagocytosis, and engulfment. This paper presents recent advances in the cytolytic and phagocytic processes of<jats:italic>Entamoeba histolytica<\/jats:italic>in context of the sequential model.<\/jats:p>","DOI":"10.1155\/2011\/926706","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T19:39:06Z","timestamp":1295552346000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["A Sequential Model of Host Cell Killing and Phagocytosis by<i>Entamoeba histolytica<\/i>"],"prefix":"10.1155","volume":"2011","author":[{"given":"Adam","family":"Sateriale","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine, The University of Vermont, Room 320 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405, USA"},{"name":"Cell and Molecular Biology Graduate Program, College of Medicine, The University of Vermont, Burlington, VT 05405, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Huston","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, The University of Vermont, Room 320 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405, USA"},{"name":"Department of Microbiology and Molecular Genetics, College of Medicine, The University of Vermont, Room 320 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"13","volume":"18","year":"1997","journal-title":"Epidemiological Bulletin"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022710"},{"issue":"10","key":"3","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1128\/IAI.65.10.4243-4249.1997","volume":"65","year":"1997","journal-title":"Infection and Immunity"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1086\/591628"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00743.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090740"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4049\/jimmunol.155.1.266","volume":"155","year":"1995","journal-title":"Journal of Immunology"},{"issue":"5","key":"8","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/infdis\/168.5.1319","volume":"168","year":"1993","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1086\/517388","volume":"177","year":"1998","journal-title":"Journal of Infectious Diseases"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1550-7408.1985.tb03033.x","volume":"32","year":"1985","journal-title":"Journal of Protozoology"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.158.5.1511","volume":"158","year":"1983","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/infdis\/154.1.27","volume":"154","year":"1986","journal-title":"Journal of Infectious Diseases"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3422-3430.2005"},{"issue":"5","key":"14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1172\/JCI110377","volume":"68","year":"1981","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"15","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1016\/S0021-9258(19)81714-3","volume":"264","year":"1989","journal-title":"Journal of Biological Chemistry"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5892-5898.2001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1086\/314610"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/infdis\/158.2.398","volume":"158","year":"1988","journal-title":"Journal of Infectious Diseases"},{"issue":"5","key":"19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1172\/JCI113199","volume":"80","year":"1987","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"20","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1128\/IAI.61.5.1772-1778.1993","volume":"61","year":"1993","journal-title":"Infection and Immunity"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.56.012302.160959"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/infdis\/144.6.539","volume":"144","year":"1981","journal-title":"Journal of Infectious Diseases"},{"issue":"5","key":"23","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/infdis\/151.5.804","volume":"151","year":"1985","journal-title":"Journal of Infectious Diseases"},{"issue":"8","key":"24","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1091\/mbc.9.8.2069","volume":"9","year":"1998","journal-title":"Molecular Biology of the Cell"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01500.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.03.005"},{"issue":"3475","key":"27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.134.3475.336","volume":"134","year":"1961","journal-title":"Science"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nature03291"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32830ce75f"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00174-07"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00015-10"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1101\/gad.4.2.190","volume":"4","year":"1990","journal-title":"Genes and Development"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00181-3"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.07.011"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.4.722-732.2005"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000929"},{"key":"37","first-page":"98","volume":"28","year":"1997","journal-title":"Archives of Medical Research"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3577"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(92)90163-E"},{"issue":"5","key":"40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1550-7408.1995.tb05916.x","volume":"42","year":"1995","journal-title":"Journal of eukaryotic microbiology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182096008396"},{"issue":"2","key":"42","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1111\/j.1550-7408.1998.tb04517.x","volume":"45","year":"1998","journal-title":"Journal of Eukaryotic Microbiology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.118-124.2006"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000434"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1557"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.10.5873-5876.2002"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(92)90250-N"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00487.x"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01030.x"},{"issue":"12","key":"50","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1128\/IAI.59.12.4681-4683.1991","volume":"59","year":"1991","journal-title":"Infection and Immunity"},{"issue":"17","key":"51","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1073\/pnas.88.17.7659","volume":"88","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01325.x"},{"issue":"1","key":"53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(95)90229-5","volume":"83","year":"1995","journal-title":"Cell"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01607.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.2.295-305.2003"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.678-683.2004"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00324-2"},{"issue":"3","key":"58","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/infdis\/152.3.542","volume":"152","year":"1985","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"59","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1084\/jem.152.2.391","volume":"152","year":"1980","journal-title":"Journal of Experimental Medicine"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1007\/BF02531048"},{"issue":"4","key":"61","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1023\/A:1002804409503","volume":"36","year":"2000","journal-title":"Chemistry of Natural Compounds"},{"issue":"3","key":"62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0300-9629(81)93008-5","volume":"69","year":"1981","journal-title":"Comparative Biochemistry and Physiology B"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1994.1107"},{"issue":"6","key":"64","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1128\/IAI.66.6.2980-2983.1998","volume":"66","year":"1998","journal-title":"Infection and Immunity"},{"issue":"9","key":"65","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1128\/IAI.65.9.3615-3621.1997","volume":"65","year":"1997","journal-title":"Infection and Immunity"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2000.00085.x"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.964-972.2003"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7911-7914.2001"},{"issue":"6","key":"69","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1128\/IAI.66.6.2980-2983.1998","volume":"66","year":"1998","journal-title":"Infection and Immunity"},{"issue":"7","key":"70","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.4049\/jimmunol.174.7.4279","volume":"174","year":"2005","journal-title":"Journal of Immunology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.03.011"},{"issue":"3","key":"72","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/infdis\/146.3.335","volume":"146","year":"1982","journal-title":"Journal of Infectious Diseases"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.1816-1823.2002"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01175.x"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.06.013"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.05.002"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2003.10.005"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.12.007"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00025-06"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040008"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1545"},{"issue":"7","key":"82","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","volume":"148","year":"1992","journal-title":"Journal of Immunology"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.11.024"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101157"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.10.007"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp941"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(07)65002-7"},{"issue":"2","key":"87","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2958.1996.00111.x","volume":"22","year":"1996","journal-title":"Molecular Microbiology"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.3.501-509.2003"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2006.02.007"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00837.x"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1274-1280.2003"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000551"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00094-07"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.086181"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.4976"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01455-07"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04040.x"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12162"},{"issue":"7","key":"99","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1177\/002215540205000713","volume":"50","year":"2002","journal-title":"Journal of Histochemistry and Cytochemistry"},{"issue":"12","key":"100","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.4049\/jimmunol.169.12.6945","volume":"169","year":"2002","journal-title":"Journal of Immunology"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.781"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.09.008"},{"issue":"2","key":"103","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1084\/jem.162.2.546","volume":"162","year":"1985","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"104","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/infdis\/143.1.83","volume":"143","year":"1981","journal-title":"Journal of Infectious Diseases"},{"issue":"8","key":"105","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1128\/IAI.55.8.1848-1853.1987","volume":"55","year":"1987","journal-title":"Infection and Immunity"},{"issue":"8","key":"106","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1242\/jcs.112.8.1191","volume":"112","year":"1999","journal-title":"Journal of Cell Science"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.06.003"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00190"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2004.01.005"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.4.827-831.2005"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00573.x"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.10.001"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.10.003"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12830-9"},{"issue":"5","key":"115","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1128\/IAI.65.5.1631-1639.1997","volume":"65","year":"1997","journal-title":"Infection and Immunity"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.03.005"}],"container-title":["Journal of Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2011\/926706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2011\/926706.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jpr\/2011\/926706.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T09:10:17Z","timestamp":1712135417000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jpr\/2011\/926706\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":117,"alternative-id":["926706","926706"],"URL":"https:\/\/doi.org\/10.1155\/2011\/926706","relation":{},"ISSN":["2090-0023","2090-0031"],"issn-type":[{"value":"2090-0023","type":"print"},{"value":"2090-0031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}