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Starzl Transplantation Institute of the University of Pittsburgh"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Allograft\/xenograft rejection is associated with \u201cpassenger leukocyte\u201d migration from the organ into recipient lymph nodes. In Study 1, we attempted to deplete leukocytes from potential kidney \u201cdonor\u201d pigs, using two regimens of total body irradiation. A dose of 700\u2009cGy was administered, followed by either 800\u2009cGy (\u201clow-dose\u201d) or 1,300\u2009cGy (\u201chigh dose\u201d) with the kidneys shielded. Neither regimen was entirely successful in depleting all leukocytes, although remaining T and 8 cell numbers were negligible. Study 2 was aimed at providing an indication of whether near-complete depletion of leukocytes had any major impact on kidney allograft survival. In non-immunosuppressed recipient pigs, survival of a kidney from a donor that received high-dose irradiation was compared with that of a kidney taken from a non-irradiated donor. Kidney graft survival was 9 and 7 days, respectively, suggesting that depletion had little impact on graft survival. The lack of effect may have been related to (i) inadequate depletion of passenger leukocytes, thus not preventing a direct T cell response, (ii) the presence of dead or dying leukocytes (antigens), thus not preventing an indirect T cell response, or (iii) constitutive expression of MHC class II and B7 molecules on the porcine vascular endothelium, activating recipient T cells.<\/jats:p>","DOI":"10.1155\/2011\/928759","type":"journal-article","created":{"date-parts":[[2011,12,18]],"date-time":"2011-12-18T21:09:44Z","timestamp":1324242584000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs"],"prefix":"10.1155","volume":"2011","author":[{"given":"Hao-Chih","family":"Tai","sequence":"first","affiliation":[{"name":"Thomas E. 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