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We recently developed a novel transgenic cystitis model (URO\u2010OVA mice) that mimics certain key aspects of IC\/PBS pathophysiology. This paper aimed to determine whether URO\u2010OVA cystitis model was responsive to intravesical dimethyl sulfoxide (DMSO) and if so identify the mechanisms of DMSO action. URO\u2010OVA mice developed acute cystitis upon adoptive transfer of OVA\u2010specific OT\u2010I splenocytes. Compared to PBS\u2010treated bladders, the bladders treated with 50% DMSO exhibited markedly reduced bladder histopathology and expression of various inflammatory factor mRNAs. Intravesical DMSO treatment also effectively inhibited bladder inflammation in a spontaneous chronic cystitis model (URO\u2010OVA\/OT\u2010I mice). Studies further revealed that DMSO could impair effector T cells in a dose\u2010dependent manner in vitro. Taken together, our results suggest that intravesical DMSO improves the bladder histopathology of IC\/PBS patients because of its ability to interfere with multiple inflammatory and bladder cell types.<\/jats:p>","DOI":"10.1155\/2011\/937061","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T19:33:44Z","timestamp":1289504024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intravesical Dimethyl Sulfoxide Inhibits Acute and Chronic Bladder Inflammation in Transgenic Experimental Autoimmune Cystitis Models"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ronald","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wujiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Kreder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.10.062"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610410001660652"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590802671031"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65195-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1031"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0874"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590310008721"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)69129-8"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37091-X"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07891.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07035.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050162"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389795"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.539"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.923"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(08)60186-X"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.10.005"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00002-9"},{"key":"e_1_2_7_19_2","first-page":"17","article-title":"Intravesical 50% dimethyl sulfoxide (Rimso-50) in treatment of interstitial cystitis","volume":"29","author":"Sant G. 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