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PP\u2010g\u2010PEG2000, PP\u2010g\u2010PEG4000, Au\u2010PP\u2010g\u2010PEG2000, and AuPP\u2010g\u2010PEG4000 were obtained via chlorination of polypropylene and polyethylene glycol in the presence of a base with a \u201cgrafting onto\u201d technique. Solvent cast films of these four copolymers with PP as a control group were embedded into five different rats. After 30 days of implantation, microscopic evaluation of inflammation and SEM analysis were done. PP had the most intense inflammatory reaction among the other polymers. PP\u2010PEG block copolymers with high molecular weight and gold\u2010nanoparticles\u2010embedded ones revealed mild inflammatory reaction independently. SEM assessment revealed punched hole\u2010like defects on the surface of all polymer samples except for PP. Graft copolymers with PEG, especially Au\u2010attached ones, have favorable soft tissue response, and inflammatory reaction becomes milder as the number of PEG side chains increases.<\/jats:p>","DOI":"10.1155\/2011\/956169","type":"journal-article","created":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T21:01:03Z","timestamp":1324846863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Soft Tissue Response to the Presence of Polypropylene\u2010G\u2010Poly(ethylene glycol) Comb\u2010Type Graft Copolymers Containing Gold Nanoparticles"],"prefix":"10.1155","volume":"2011","author":[{"given":"Derya 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