{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:15:06Z","timestamp":1791267306553,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Diabetes Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Arterial stiffness is increased in type 1 diabetes (T1D), before any clinical complications of the disease are evident. The aim of the present paper was to investigate the association between cardiac autonomic function and arterial stiffness in a cohort of young T1D patients, without history of hypertension and any evidence of macrovascular and\/or renal disease. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV). Cardiac autonomic function was assessed by the cardiovascular tests proposed by Ewing and Clarke. Patients with a high cardiac autonomic neuropathy score (4) had significantly higher PWV than those with a low score (0-1). A negative, heart rate-independent, correlation between PWV and heart rate variation during respiration was observed (). In multivariable analysis, index was the strongest correlate of PWV (<jats:italic>\u03b2<\/jats:italic>-coefficient = \u22120.326, ). Cardiac parasympathetic function is a strong predictor of large arterial stiffness, in young T1D patients free of macrovascular and renal complications.<\/jats:p>","DOI":"10.1155\/2011\/957901","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T15:00:57Z","timestamp":1311519657000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes"],"prefix":"10.1155","volume":"2011","author":[{"given":"S.","family":"Liatis","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Alexiadou","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tsiakou","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Makrilakis","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Katsilambros","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-2534","authenticated-orcid":true,"given":"N.","family":"Tentolouris","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Diabetes Center, Athens University Medical School and General Hospital of Athens \u201cLaiko\u201d, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/01.ATV.13.1.90","volume":"13","year":"1993","journal-title":"Arteriosclerosis and Thrombosis"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.050"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000164580.39991.3d"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.099031"},{"issue":"5","key":"5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/01.HYP.37.5.1236","volume":"37","year":"2001","journal-title":"Hypertension"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033824.02722.F7"},{"issue":"6","key":"7","first-page":"H1839","volume":"276","year":"1999","journal-title":"American Journal of Physiology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051257"},{"issue":"12","key":"9","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.2337\/diacare.24.12.2102","volume":"24","year":"2001","journal-title":"Diabetes Care"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.1.36"},{"issue":"6","key":"11","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1161\/01.CIR.88.6.2510","volume":"88","year":"1993","journal-title":"Circulation"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diacare.19.3.257","volume":"19","year":"1996","journal-title":"Diabetes Care"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(92)90049-Q"},{"issue":"234","key":"14","first-page":"957","volume":"61","year":"1986","journal-title":"Quarterly Journal of Medicine"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634949"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2337\/diacare.7.5.447","volume":"7","year":"1984","journal-title":"Diabetes Care"},{"issue":"7960","key":"17","first-page":"601","volume":"1","year":"1976","journal-title":"Lancet"},{"issue":"10","key":"18","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.2337\/diacare.24.10.1793","volume":"24","year":"2001","journal-title":"Diabetes Care"},{"issue":"2","key":"19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/oxfordjournals.ndt.a027826","volume":"13","year":"1998","journal-title":"Nephrology Dialysis Transplantation"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00079.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00402.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001751"},{"key":"23","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2337\/diacare.15.8.1095","volume":"15","year":"1992","journal-title":"Diabetes Care"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90153-9"},{"issue":"5","key":"26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diacare.8.5.491","volume":"8","year":"1985","journal-title":"Diabetes Care"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00015-0"},{"issue":"7","key":"29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2337\/diacare.13.7.719","volume":"13","year":"1990","journal-title":"Diabetes Care"},{"issue":"5","key":"30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2337\/diacare.18.5.618","volume":"18","year":"1995","journal-title":"Diabetes Care"},{"issue":"11","key":"31","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/BF00408358","volume":"34","year":"1991","journal-title":"Diabetologia"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051600"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030119"},{"issue":"1","key":"34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1475-097X.1993.tb00316.x","volume":"13","year":"1993","journal-title":"Clinical Physiology"},{"issue":"4","key":"35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2337\/diab.31.4.339","volume":"31","year":"1982","journal-title":"Diabetes"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1553"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2003.01279.x"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1139\/Y10-095"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050851"},{"issue":"4 i","key":"40","first-page":"598","volume":"34","year":"1999","journal-title":"Hypertension"},{"issue":"5","key":"41","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/01.HYP.30.5.1085","volume":"30","year":"1997","journal-title":"Hypertension"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917080-00011"},{"issue":"2","key":"43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/01.HYP.26.2.348","volume":"26","year":"1995","journal-title":"Hypertension"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199607000-00013"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001755"},{"issue":"6","key":"46","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1165\/ajrcmb.17.6.2830","volume":"17","year":"1997","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1936"}],"container-title":["Experimental Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2011\/957901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2011\/957901.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2011\/957901.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T23:37:06Z","timestamp":1497915426000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jdr\/2011\/957901\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":46,"alternative-id":["957901","957901"],"URL":"https:\/\/doi.org\/10.1155\/2011\/957901","relation":{},"ISSN":["1687-5214","1687-5303"],"issn-type":[{"value":"1687-5214","type":"print"},{"value":"1687-5303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}