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World Health Organization figures estimated that over 90 million new cases of genital<jats:italic>C. trachomatis<\/jats:italic>infections occur worldwide each year. A vaccination program is considered to be the best approach to reduce the prevalence of<jats:italic>C. trachomatis<\/jats:italic>infections, as it would be much cheaper and have a greater impact on controlling<jats:italic>C. trachomatis<\/jats:italic>infections worldwide rather than a screening program or treating infections with antibiotics. Currently, there are no vaccines available which effectively protect against a<jats:italic>C. trachomatis<\/jats:italic>genital infection despite the many efforts that have been made throughout the years. In this paper, the many attempts to develop a protective vaccine against a genital<jats:italic>C. trachomatis<\/jats:italic>infection will be reviewed.<\/jats:p>","DOI":"10.1155\/2011\/963513","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T21:41:01Z","timestamp":1309124461000},"page":"1-9","source":"Crossref","is-referenced-by-count":33,"title":["<i>Chlamydia trachomatis<\/i>Vaccine Research through the Years"],"prefix":"10.1155","volume":"2011","author":[{"given":"Katelijn","family":"Schautteet","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelien","family":"De Clercq","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, 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