{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T23:49:54Z","timestamp":1768866594334,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"crossref","award":["2009-0433"],"award-info":[{"award-number":["2009-0433"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004200","name":"Stiftelsen Olle Engkvist Byggm\u00e4stare","doi-asserted-by":"publisher","award":["2009-0433"],"award-info":[{"award-number":["2009-0433"]}],"id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To quantify the degree of plasma volume expansion that occurs during an intravenous glucose tolerance test (IVGTT). <jats:italic>Methods<\/jats:italic>. Twenty healthy volunteers (mean age, 28 years) underwent IVGTTs in which 0.3\u2009g\/kg of glucose 30% was injected as a bolus over 1\u2009min. Twelve blood samples were collected over 75\u2009min. The plasma glucose and blood hemoglobin concentrations were used to calculate the volume distribution (<jats:italic>V<\/jats:italic><jats:sub><jats:italic>d<\/jats:italic><\/jats:sub>) and the clearance (<jats:italic>C<\/jats:italic><jats:italic>L<\/jats:italic>) of both the exogenous glucose and the injected fluid volume. <jats:italic>Results<\/jats:italic>. The IVGTT caused a virtually instant plasma volume expansion of 10%. The half\u2010life of the glucose averaged 15\u2009min and the plasma volume expansion 16\u2009min. Correction of the fluid kinetic model for osmotic effects after injection reduced <jats:italic>C<\/jats:italic><jats:italic>L<\/jats:italic> for the infused volume by 85%, which illustrates the strength of osmosis in allocating fluid back to the intracellular fluid space. Simulations indicated that plasma volume expansion can be reduced to 60% by increasing the injection time from 1 to 5\u2009min and reducing the glucose load from 0.3 to 0.2\u2009g\/kg. <jats:italic>Conclusion<\/jats:italic>. A regular IVGTT induced an acute plasma volume expansion that peaked at 10% despite the fact that only 50\u201380\u2009mL of fluid were administered.<\/jats:p>","DOI":"10.1155\/2011\/965075","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T19:02:21Z","timestamp":1317236541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test"],"prefix":"10.1155","volume":"2011","author":[{"given":"Robert G.","family":"Hahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1258\/000456307780945778"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00645.2007"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010199816070\u201000001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200206000\u201000016"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20104804(03)00128\u20108"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg102"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh095"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20104682\u20108\u201012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.6.834"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050361"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2011\/965075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2011\/965075.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2011\/965075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:20:19Z","timestamp":1718695219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2011\/965075"}},"subtitle":[],"editor":[{"given":"Yoram","family":"Louzoun","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1155\/2011\/965075"],"URL":"https:\/\/doi.org\/10.1155\/2011\/965075","archive":["Portico"],"relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2011-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"965075"}}