{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:34:47Z","timestamp":1773786887205,"version":"3.50.1"},"reference-count":41,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Primary hyperparathyroidism (PHPT) may be associated with arterial hypertension. The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial. This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free calcium in platelets in 15 hypertensive patients with hypercalcaemic PHPT before and after successful parathyroidectomy and to compare them with 5 pre-hypertensive patients with normocalcaemic PHPT, 8 normotensive patients with hypercalcaemic PHPT and 15 normal controls. Hypertensive patients with hypercalcaemic PHPT had slightly higher levels of pressor hormones (), enhanced cardiovascular reactivity to norepinephrine () and increased cytosolic calcium in platelets () than controls. Pre-hypertensive patients with normocalcaemic PHPT had intermediate values of increased cardiovascular reactivity and cytosolic calcium. Normotensive patients with hypercalcaemic PHPT and normotensive controls had comparable pressor hormone concentrations and intracellular calcium levels. Successful parathyroidectomy was associated with normal blood pressure values and normalisation of pressor hormone concentrations, cardiovascular pressor reactivity and cytosolic free calcium. Our results suggest that parathyroid hypertension is mediated\/maintained, at least in part, by functional alterations of vascular smooth muscle cells and can be cured by parathyroidectomy in those patients who do not have primary hypertension.<\/jats:p>","DOI":"10.1155\/2011\/974647","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T20:16:43Z","timestamp":1299529003000},"page":"1-6","source":"Crossref","is-referenced-by-count":35,"title":["Hypertension Secondary to PHPT: Cause or Coincidence?"],"prefix":"10.1155","volume":"2011","author":[{"given":"Helmut","family":"Schiffl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine-Campus Innenstadt, University Hospital, University of Munich, 80336 Munich, Germany"},{"name":"KfH Nierenzentrum M\u00fcnchen-Laim, Elsenheimerstra\u03b2e 63, 80687 M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne M.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Campus Innenstadt, University Hospital, University of Munich, 80336 Munich, Germany"},{"name":"SRH Wald-Klinikum Gera, 2. Medizinische Klinik, 07548 Gera, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021370"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021404"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02173"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/10641960903254471"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.024"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001907"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0259"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-1067"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.141.13.1761"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(92)90227-T"},{"issue":"1","key":"12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ki.1981.109","volume":"20","year":"1981","journal-title":"Kidney International"},{"issue":"3","key":"13","first-page":"147","volume":"17","year":"1991","journal-title":"Mineral and Electrolyte Metabolism"},{"issue":"1\u20133","key":"14","first-page":"77","volume":"21","year":"1995","journal-title":"Mineral and Electrolyte Metabolism"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1161\/01.HYP.4.3.452","volume":"4","year":"1982","journal-title":"Hypertension"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00130-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101422"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01076.x"},{"issue":"5","key":"19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF03348986","volume":"17","year":"1994","journal-title":"Journal of Endocrinological Investigation"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100309"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.1982.169","volume":"22","year":"1982","journal-title":"Kidney International"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","volume":"58","year":"1978","journal-title":"Circulation"},{"issue":"6","key":"23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","volume":"57","year":"1986","journal-title":"American Journal of Cardiology"},{"issue":"13","key":"24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/BF01718029","volume":"67","year":"1989","journal-title":"Klinische Wochenschrift"},{"issue":"5","key":"26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000174161","volume":"20","year":"1997","journal-title":"Kidney and Blood Pressure Research"},{"issue":"17","key":"27","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1056\/NEJM198404263101705","volume":"310","year":"1984","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"28","first-page":"366","volume":"10","year":"1995","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"5, supplement 2","key":"29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0272-6386(93)70095-G","volume":"21","year":"1993","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"30","first-page":"97","volume":"2","year":"1997","journal-title":"European Journal of Medical Research"},{"key":"31","first-page":"197","volume":"46","year":"1993","journal-title":"Drugs"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01297-8"},{"issue":"11","key":"33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/BF03349828","volume":"18","year":"1995","journal-title":"Journal of Endocrinological Investigation"},{"issue":"2","key":"34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/cs0780127","volume":"78","year":"1990","journal-title":"Clinical Science"},{"issue":"11","key":"35","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/ajh\/5.11.823","volume":"5","year":"1992","journal-title":"American Journal of Hypertension"},{"issue":"1","key":"36","first-page":"S11","volume":"12","year":"1994","journal-title":"Journal of Hypertension, Supplement"},{"key":"37","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/00005344-199406032-00004","volume":"23","year":"1994","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90285-3"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.650"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03520.x"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/974647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/974647.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2011\/974647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:42:51Z","timestamp":1497904971000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ije\/2011\/974647\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":41,"alternative-id":["974647","974647"],"URL":"https:\/\/doi.org\/10.1155\/2011\/974647","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}