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Gastric carcinogenesis in humans is affected by numerous factors and progresses slowly over years. When using animal models with the possibility of intervention, a complex process can be dissected by studying the role of hypergastrinemia in carcinogenesis within a relatively short period of time. We have reviewed findings from relevant models where gastric changes in animal models of long\u2010term hypergastrinemia have been investigated. In all species where long\u2010term hypergastrinemia has been induced, there is an increased risk of gastric malignancy. There is evidence that hypergastrinemia is a common causative factor in carcinogenesis in the oxyntic mucosa, while other cofactors may vary in the different models.<\/jats:p>","DOI":"10.1155\/2011\/975479","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T19:34:57Z","timestamp":1290627297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Animal Models to Study the Role of Long\u2010Term Hypergastrinemia in Gastric Carcinogenesis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Reidar","family":"Fossmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Qvigstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom Chr.","family":"Martinsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u2300yvind","family":"Hauso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge L.","family":"Waldum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,24]]},"reference":[{"key":"e_1_2_4_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930470204"},{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310006900"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00182-8"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199911)189:3<394::AID-PATH444>3.0.CO;2-P"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025076"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229064"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0283"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(10)62991-5","article-title":"Exocrine and endocrine gastric mucosal changes under medical or surgical antireflux therapy: results of a 5-year follow-up in the LOTUS trial","volume":"138","author":"Fiocca R.","year":"2010","journal-title":"Gastroenterology"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.6.698"},{"key":"e_1_2_4_11_2","first-page":"613","article-title":"Histamine dependence of pentagastrin-stimulated gastric acid secretion in rats","volume":"65","author":"Shankley N. 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