{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:03:49Z","timestamp":1780398229353,"version":"3.54.1"},"reference-count":76,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61173096"],"award-info":[{"award-number":["61173096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51075367"],"award-info":[{"award-number":["51075367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["60870002"],"award-info":[{"award-number":["60870002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61173096"],"award-info":[{"award-number":["61173096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51075367"],"award-info":[{"award-number":["51075367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["60870002"],"award-info":[{"award-number":["60870002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61173096"],"award-info":[{"award-number":["61173096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51075367"],"award-info":[{"award-number":["51075367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["60870002"],"award-info":[{"award-number":["60870002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial S&T Department","award":["61173096"],"award-info":[{"award-number":["61173096"]}]},{"name":"Zhejiang Provincial S&T Department","award":["51075367"],"award-info":[{"award-number":["51075367"]}]},{"name":"Zhejiang Provincial S&T Department","award":["60870002"],"award-info":[{"award-number":["60870002"]}]},{"name":"Zhejiang Provincial S&T Department","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}]},{"name":"Zhejiang Provincial S&T Department","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}]},{"name":"Zhejiang Provincial S&T Department","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}]},{"name":"Zhejiang Provincial S&T Department","award":["61173096"],"award-info":[{"award-number":["61173096"]}]},{"name":"Zhejiang Provincial S&T Department","award":["51075367"],"award-info":[{"award-number":["51075367"]}]},{"name":"Zhejiang Provincial S&T Department","award":["60870002"],"award-info":[{"award-number":["60870002"]}]},{"name":"Zhejiang Provincial S&T Department","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}]},{"name":"Zhejiang Provincial S&T Department","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}]},{"name":"Zhejiang Provincial S&T Department","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["61173096"],"award-info":[{"award-number":["61173096"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["51075367"],"award-info":[{"award-number":["51075367"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["60870002"],"award-info":[{"award-number":["60870002"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["2010R10006"],"award-info":[{"award-number":["2010R10006"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["2010C33095"],"award-info":[{"award-number":["2010C33095"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["R1110679"],"award-info":[{"award-number":["R1110679"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>This paper summarizes the recent advances in image processing methods for morphological cell analysis. The topic of morphological analysis has received much attention with the increasing demands in both bioinformatics and biomedical applications. Among many factors that affect the diagnosis of a disease, morphological cell analysis and statistics have made great contributions to results and effects for a doctor. Morphological cell analysis finds the cellar shape, cellar regularity, classification, statistics, diagnosis, and so forth. In the last 20 years, about 1000 publications have reported the use of morphological cell analysis in biomedical research. Relevant solutions encompass a rather wide application area, such as cell clumps segmentation, morphological characteristics extraction, 3D reconstruction, abnormal cells identification, and statistical analysis. These reports are summarized in this paper to enable easy referral to suitable methods for practical solutions. Representative contributions and future research trends are also addressed.<\/jats:p>","DOI":"10.1155\/2012\/101536","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T16:00:37Z","timestamp":1326124837000},"page":"1-10","source":"Crossref","is-referenced-by-count":83,"title":["Recent Advances in Morphological Cell Image Analysis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Shengyong","family":"Chen","sequence":"first","affiliation":[{"name":"College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"},{"name":"DreamSciTech Consulting, Shenzhen 518054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China"},{"name":"Department of Informatics, University of Hamburg, 22527 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Informatics, University of Hamburg, 22527 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20997"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2010.03464.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1118\/1.3512799"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1118\/1.3495538"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2011.01.008"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2010.2087030"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2008.30"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20874"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.05.010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-4-33"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1039\/c0ib00036a"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0512-8"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq194"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2009.10.008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1747-1028-4-5"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2009.10.014"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2027813"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s11265-008-0214-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.016"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/0933-3657(95)00021-6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20527"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20204"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01696155"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1080\/14639230500077444"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10183"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-0030-2"},{"issue":"24","key":"27","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1364\/OE.10.001431","volume":"10","year":"2002","journal-title":"Optics Express"},{"issue":"7","key":"28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1089\/dna.1993.12.629","volume":"12","year":"1993","journal-title":"DNA and Cell Biology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070280511"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390207"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)00109-T"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(93)90068-V"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20263"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2005.00698.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0169(1996)35:3<237::AID-CM6>3.0.CO;2-5"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00130505"},{"issue":"3","key":"37","first-page":"135","volume":"5","year":"1993","journal-title":"Analytical Cellular Pathology"},{"issue":"4","key":"38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF02345082","volume":"40","year":"2002","journal-title":"Medical and Biological Engineering and Computing"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20244"},{"issue":"4","key":"40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1083\/jcb.114.4.701","volume":"114","year":"1991","journal-title":"Journal of Cell Biology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2009.05.010"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1109\/TCSI.2008.2008273"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1170\/T784"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/24\/1\/309"},{"issue":"6","key":"45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/rtim.2002.0288","volume":"8","year":"2002","journal-title":"Real-Time Imaging"},{"issue":"3","key":"46","first-page":"159","volume":"11","year":"2001","journal-title":"Bio-Medical Materials and Engineering"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4825(00)00003-2"},{"issue":"3","key":"48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1097-0029(19971101)39:3<305::AID-JEMT9>3.0.CO;2-I","volume":"39","year":"1997","journal-title":"Microscopy Research and Technique"},{"issue":"10","key":"49","first-page":"1","volume":"30","year":"2009","journal-title":"Journal of Statistical Software"},{"issue":"1","key":"50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1179\/his.2001.24.1.59","volume":"24","year":"2001","journal-title":"Journal of Histotechnology"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2011.2106499"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.4015\/S1016237210001980"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cviu.2008.08.011"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2007.11.006"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-007-0368-5"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20170"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20082"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20098"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2008.12.001"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1109\/83.350817"},{"issue":"7","key":"61","first-page":"1217","volume":"35","year":"1994","journal-title":"Journal of Nuclear Medicine"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20404"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1007\/s00500-005-0458-z"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2005.01531.x"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1007\/BF01457662"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000288"},{"issue":"2","key":"67","first-page":"85","volume":"12","year":"1996","journal-title":"Analytical Cellular Pathology"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1109\/83.935033"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1109\/83.902291"},{"key":"71","first-page":"125","volume":"2","year":"2001","journal-title":"Journal of Machine Learning Research"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-87732-5-56"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-009-0058-3"},{"issue":"3","key":"74","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00269092","volume":"100","year":"1993","journal-title":"Histochemistry"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000030700.48612.0b"},{"issue":"4","key":"76","first-page":"213","volume":"11","year":"1998","journal-title":"Machine Vision and Applications"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.06.004"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/101536.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/101536.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/101536.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T08:28:54Z","timestamp":1497947334000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2012\/101536\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":76,"alternative-id":["101536","101536"],"URL":"https:\/\/doi.org\/10.1155\/2012\/101536","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}