{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:13:58Z","timestamp":1785500038207,"version":"3.56.0"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973240"],"award-info":[{"award-number":["30973240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology Research International"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>A growing body of evidence demonstrates that susceptibility and progression of both acute and chronic central nervous system disease in the newborn is closely associated with an innate immune response that can manifest from either direct infection and\/or infection-triggered damage. A common feature of many of these diseases is the systemic exposure of the neonate to bacterial infections that elicit brain inflammation. In recent years, the importance of innate immune receptors in newborn brain injury, the so-called Toll-like receptors, has been demonstrated. In this paper we will discuss how neonatal sepsis, with particular emphasis on<jats:italic>Escherichia coli<\/jats:italic>, coagulase-negative staphylococci, and group B streptococcal infections in preterm infants, and Toll-like receptor-mediated inflammation can increase the vulnerability of the newborn brain to injury.<\/jats:p>","DOI":"10.1155\/2012\/102153","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T19:00:41Z","timestamp":1320260441000},"page":"1-6","source":"Crossref","is-referenced-by-count":34,"title":["Infection-Induced Vulnerability of Perinatal Brain Injury"],"prefix":"10.1155","volume":"2012","author":[{"given":"Carina","family":"Mallard","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 432, 40530 G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 432, 40530 G\u00f6teborg, Sweden"},{"name":"Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041367"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","volume":"42","year":"1997","journal-title":"Pediatric Research"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.wco.0000162851.44897.8f","volume":"18","year":"2005","journal-title":"Current Opinion in Neurology"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0022-510X(73)90020-8","volume":"18","year":"1973","journal-title":"Journal of the Neurological Sciences"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1542\/peds.76.3.415","volume":"76","year":"1985","journal-title":"Pediatrics"},{"issue":"7078","key":"6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/bmj.314.7078.404","volume":"314","year":"1997","journal-title":"British Medical Journal"},{"issue":"1","key":"7","first-page":"41","volume":"14","year":"1994","journal-title":"Journal of Perinatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162200000670"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.02.033"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.04.057"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e31805341f1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.19.2357"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.042"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.058"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1998.00081.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000168749.82105.64"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2004.09.002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.038539"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2005.074"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00193-7"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108888"},{"issue":"4","key":"23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9378(97)70271-0","volume":"177","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2005.03.015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.093"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.10.016"},{"issue":"2","key":"27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ana.22190","volume":"69","year":"2011","journal-title":"Annals of Neurology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.04.001"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.03.006"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012657"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0552"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1086\/426444"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00046-6"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01563-0"},{"issue":"2","key":"36","first-page":"F89","volume":"88","year":"2003","journal-title":"Archives of Disease in Childhood"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1086\/425321"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2002.019"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3281a7ec98"},{"issue":"1","key":"40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.jp.7200474","volume":"21","year":"2001","journal-title":"Journal of Perinatology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01111-3"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31819368ac"},{"issue":"5","key":"43","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0022-3476(85)80342-5","volume":"106","year":"1985","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"44","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00005072-199507000-00007","volume":"54","year":"1995","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"11","key":"45","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1172\/JCI119084","volume":"98","year":"1996","journal-title":"The Journal of Clinical Investigation"},{"issue":"11","key":"46","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/jnen\/61.11.1013","volume":"61","year":"2002","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-53"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.07.019"},{"issue":"10","key":"49","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.4049\/jimmunol.165.10.5780","volume":"165","year":"2000","journal-title":"Journal of Immunology"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01551-05"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.01.005"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000228323.32445.7d"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2140-08.2008"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606016"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06778.x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-45"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1629"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000034224.13885.BE"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022368915400"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338068"},{"key":"61"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816X.2001.01474.x"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2003.00174.x"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900762"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1432609100"},{"issue":"4","key":"66","first-page":"776","volume":"24","year":"2010","journal-title":"Brain, Behavior, and Immunity"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181df5f6b"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-55"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200001)47:1<54::AID-ANA10>3.0.CO;2-Y"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22489"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000163513.03619.8D"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000263870.91811.6f"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000191140.87314.ce"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.048"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.574004"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21151"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.06.016"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21066"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019583"},{"issue":"1","key":"81","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003","volume":"23","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.08.008"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.09.012"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21673"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.07.012"}],"container-title":["Neurology Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2012\/102153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2012\/102153.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2012\/102153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T04:19:33Z","timestamp":1639455573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/nri\/2012\/102153\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":84,"alternative-id":["102153","102153"],"URL":"https:\/\/doi.org\/10.1155\/2012\/102153","relation":{},"ISSN":["2090-1852","2090-1860"],"issn-type":[{"value":"2090-1852","type":"print"},{"value":"2090-1860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}