{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:17:48Z","timestamp":1791091068504,"version":"4.1.0"},"reference-count":60,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>K<jats:sup>+<\/jats:sup>channels selectively transport K<jats:sup>+<\/jats:sup>ions across cell membranes and play a key role in regulating the physiology of excitable and nonexcitable cells. Their activation allows the cell to repolarize after action potential firing and reduces excitability, whereas channel inhibition increases excitability. In eukaryotes, the pharmacology and pore topology of several structural classes of K<jats:sup>+<\/jats:sup>channels have been well characterized in the past two decades. This information has come about through the extensive use of scorpion toxins. We have participated in the isolation and in the characterization of several structurally distinct families of scorpion toxin peptides exhibiting different K<jats:sup>+<\/jats:sup>channel blocking functions. In particular, the venom from the Moroccan scorpion<jats:italic>Androctonus mauretanicus mauretanicus<\/jats:italic>provided several high-affinity blockers selective for diverse K<jats:sup>+<\/jats:sup>channels<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u2009\u2009<\/mml:mi><mml:msub><mml:mrow><mml:mtext>(SK<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>Ca<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u2009\u2009<\/mml:mi><mml:msub><mml:mrow><mml:mtext>K<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>v<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>4.x, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u2009\u2009<\/mml:mi><mml:msub><mml:mrow><mml:mtext>K<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>v<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>1.x K<jats:sup>+<\/jats:sup>channel families). In this paper, we summarize our work on these toxin\/channel interactions.<\/jats:p>","DOI":"10.1155\/2012\/103608","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T21:01:26Z","timestamp":1337288486000},"page":"1-9","source":"Crossref","is-referenced-by-count":23,"title":["Potassium Channels Blockers from the Venom of<i>Androctonus mauretanicus mauretanicus<\/i>"],"prefix":"10.1155","volume":"2012","author":[{"given":"Marie-France","family":"Martin-Eauclaire","sequence":"first","affiliation":[{"name":"Aix-Marseille University, CNRS, UMR 7286, CRN2M, Facult\u00e9 de M\u00e9decine secteur Nord, CS80011, Boulevard Pierre Dramard, 13344 Marseille Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre E.","family":"Bougis","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, CNRS, UMR 7286, CRN2M, Facult\u00e9 de M\u00e9decine secteur Nord, CS80011, Boulevard Pierre Dramard, 13344 Marseille Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","first-page":"683","volume-title":"Scorpion neurotoxins: effects and mechanisms","year":"1995"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01167-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.09.006"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01174-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nature07473"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201110614"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01398-X"},{"issue":"5037","key":"8","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1720574","volume":"254","year":"1991","journal-title":"Science"},{"key":"9","series-title":"Results and Problems in Cell Differentiation","volume":"44","year":"2007"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.10"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116269"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90169-E"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nature04649"},{"issue":"33","key":"14","doi-asserted-by":"crossref","first-page":"30040","DOI":"10.1074\/jbc.M111258200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7370-x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03652-9"},{"key":"17","first-page":"295","volume-title":"Identification des param\u00e8tres influen\u00e7ant la prise en charge de l'envenimation scorpionique au Maroc","year":"2006"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0041-0101(85)90114-X","volume":"23","year":"1985","journal-title":"Toxicon"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(91)90078-6"},{"issue":"3","key":"20","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0021-9258(18)45993-5","volume":"267","year":"1992","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"21","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1021\/bi00062a005","volume":"32","year":"1993","journal-title":"Biochemistry"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03294.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.12.012"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90104-3"},{"issue":"20","key":"60","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.85.20.7443","volume":"85","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1399-3011.1996.tb00870.x","volume":"48","year":"1996","journal-title":"International Journal of Peptide and Protein Research"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.10.029"},{"key":"28","first-page":"41","volume":"16","year":"1999","journal-title":"Perspectives in Drug Discovery and Design"},{"issue":"8","key":"26","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1016\/S0021-9258(19)39626-7","volume":"265","year":"1990","journal-title":"Journal of Biological Chemistry"},{"issue":"21","key":"27","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.1016\/S0021-9258(19)81496-5","volume":"263","year":"1988","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"29","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1432-1033.1991.tb15860.x","volume":"196","year":"1991","journal-title":"European Journal of Biochemistry"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.tb20730.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00095-5"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00235398","volume":"147","year":"1995","journal-title":"Journal of Membrane Biology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00622-9"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00816.x"},{"issue":"2","key":"35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.166.2.936","volume":"166","year":"2001","journal-title":"Journal of Immunology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301213"},{"issue":"3","key":"37","first-page":"943","volume":"291","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00356-9"},{"issue":"35","key":"39","doi-asserted-by":"crossref","first-page":"26302","DOI":"10.1016\/S0021-9258(19)74315-4","volume":"268","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900256"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1430"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.06.023"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.01.018"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00259-5"},{"issue":"1-3","key":"46","first-page":"31","volume":"501","year":"2001","journal-title":"FEBS Letters"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00212-X"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.12.002"},{"issue":"3","key":"49","first-page":"491","volume":"51","year":"1997","journal-title":"Molecular Pharmacology"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb11293.x"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1004-8"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05020.x"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.07.008"},{"issue":"6","key":"53","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1523\/JNEUROSCI.5297-11.2012","volume":"32","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1038\/nature03873"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-9639(02)00557-5"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.097360"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00080-4"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031324"}],"container-title":["Journal of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jt\/2012\/103608.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jt\/2012\/103608.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jt\/2012\/103608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T17:02:45Z","timestamp":1713978165000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jt\/2012\/103608\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":60,"alternative-id":["103608","103608"],"URL":"https:\/\/doi.org\/10.1155\/2012\/103608","relation":{},"ISSN":["1687-8191","1687-8205"],"issn-type":[{"value":"1687-8191","type":"print"},{"value":"1687-8205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}