{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:01:15Z","timestamp":1791518475085,"version":"4.3.4"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Granulomatosis with polyangiitis (Wegener\u2019s) (GPA) may mimic IgG4-related disease (IgG4-RD) on histologic examination of some biopsies, especially those from head and neck sites. IgG4 immunostain is often performed in this context for differential diagnosis with IgG4-RD. However, the prevalence of IgG4+ cells in GPA has not been explored. We examined the IgG4+ cells in 26 cases confirmed as GPA by a thorough clinical and pathologic assessment. Twenty-six biopsies consisted of 14 sinonasal\/oral cavity\/nasopharynx, 7 orbit\/periorbital, 3 lung\/pleura, 1 iliac fossa\/kidney, and 1 dura specimens. Eight of 26 (31%) biopsies revealed increased IgG4+ cells (&gt;30\/HPF and &gt;40% in IgG4+\/IgG+ ratio). The IgG4+ cells and IgG4+\/IgG+ ratio ranged 37\u2013137\/hpf and 44\u201383%, respectively. Eight biopsies with increased IgG4+ cells were from sinonasal<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mrow><mml:mo>(<\/mml:mo><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:mrow><mml:mo>)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>or orbital\/periorbital<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mrow><mml:mo>(<\/mml:mo><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:mrow><mml:mo>)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>sites. In conclusion, increased IgG4+ cells are not uncommonly seen in sinonasal or orbital\/periorbital biopsies of GPA, which could pose as a diagnostic pitfall.<\/jats:p>","DOI":"10.1155\/2012\/121702","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T21:00:51Z","timestamp":1334178051000},"page":"1-6","source":"Crossref","is-referenced-by-count":69,"title":["Increased IgG4-Positive Plasma Cells in Granulomatosis with Polyangiitis: A Diagnostic Pitfall of IgG4-Related Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Sing Yun","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Keogh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, 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