{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:19:55Z","timestamp":1767165595152,"version":"build-2238731810"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 98-2320-B-039-042-MY3"],"award-info":[{"award-number":["NSC 98-2320-B-039-042-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["DOH101-TD-B-111-004"],"award-info":[{"award-number":["DOH101-TD-B-111-004"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","award":["NSC 98-2320-B-039-042-MY3"],"award-info":[{"award-number":["NSC 98-2320-B-039-042-MY3"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","award":["DOH101-TD-B-111-004"],"award-info":[{"award-number":["DOH101-TD-B-111-004"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    We used the carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) induced liver cirrhosis model to test the molecular mechanism of action involved in cirrhosis-associated cardiac hypertrophy and the effectiveness of\n                    <jats:italic>Ocimum gratissimum<\/jats:italic>\n                    extract (OGE) and silymarin against cardiac hypertrophy. We treated male wistar rats with CCl\n                    <jats:sub>4<\/jats:sub>\n                    and either OGE (0.02\u2009g\/kg B.W. or 0.04\u2009g\/kg B.W.) or silymarin (0.2\u2009g\/kg B.W.). Cardiac eccentric hypertrophy was induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    along with cirrhosis and increased expression of cardiac hypertrophy related genes NFAT, TAGA4, and NBP, and the interleukin-6 (IL-6) signaling pathway related genes MEK5, ERK5, JAK, and STAT3. OGE or silymarin co-treatment attenuated CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced cardiac abnormalities, and lowered expression of genes which were elevated by this hepatotoxin. Our results suggest that the IL-6 signaling pathway may be related to CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced cardiac hypertrophy. OGE and silymarin were able to lower liver fibrosis, which reduces the chance of cardiac hypertrophy perhaps by lowering the expressions of IL-6 signaling pathway related genes. We conclude that treatment of cirrhosis using herbal supplements is a viable option for protecting cardiac tissues against cirrhosis-related cardiac hypertrophy.\n                  <\/jats:p>","DOI":"10.1155\/2012\/139045","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T16:00:25Z","timestamp":1352217625000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Herbal Supplement Ameliorates Cardiac Hypertrophy in Rats with CCl\n                    <sub>4<\/sub>\n                    -Induced Liver Cirrhosis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ping-Chun","family":"Li","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery, China Medical University Hospital, Taichung 40402, Taiwan"},{"name":"Department of Life Science, Tunghai University, Taichung 40704, 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiying","family":"Pai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, China Medical University Hospital, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hai","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Kuo","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, 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