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After providing a comprehensive time-domain definition of the various forms of connectivity observed in MV processes, we particularize them to MV autoregressive (MVAR) processes and derive the corresponding frequency-domain measures. Then, we discuss the theoretical interpretation of these MVAR-based connectivity measures, showing that each of them reflects a specific time-domain connectivity definition and how this results in the description of peculiar aspects of the information transfer in MV processes. Furthermore, issues related to the practical utilization of these measures on real-time series are pointed out, including MVAR model estimation and significance assessment. Finally, limitations and pitfalls arising from model mis-specification are discussed, indicating possible solutions and providing practical recommendations for a safe computation of the connectivity measures. An example of estimation of the presented measures from multiple EEG signals recorded during a combined visuomotor task is also reported, showing how evaluation of coupling and causality in the frequency domain may help describing specific neurophysiological mechanisms.<\/jats:p>","DOI":"10.1155\/2012\/140513","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T17:01:16Z","timestamp":1337014876000},"page":"1-18","source":"Crossref","is-referenced-by-count":112,"title":["Measuring Connectivity in Linear Multivariate Processes: Definitions, Interpretation, and Practical Analysis"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-5348","authenticated-orcid":true,"given":"Luca","family":"Faes","sequence":"first","affiliation":[{"name":"Laboratorio Biosegnali, Dipartimento di Fisica & BIOtech, Universit\u00e0 di Trento, via delle Regole 101, 38123 Mattarello, Trento, 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