{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:25Z","timestamp":1788872365095,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["2001-1-1322"],"award-info":[{"award-number":["2001-1-1322"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Increased childhood weight gain has been associated with later adiposity. Whether excess early postnatal weight gain plays a role in childhood abdominal fat is unknown.\n                    <jats:italic>Design<\/jats:italic>\n                    . In the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), birth cohort weight and length from birth to age 3 months were obtained. In the first 316 five-year-olds, intra-abdominal and subcutaneous fat were measured ultrasonographically. Individual weight and length gain rates were assessed in each child. Internal\n                    <jats:italic>Z<\/jats:italic>\n                    -scores of weight for length gain (WLG) were calculated. Multiple imputation was used to deal with missing covariates.\n                    <jats:italic>Results<\/jats:italic>\n                    . Per-1-unit increase in\n                    <jats:italic>Z<\/jats:italic>\n                    -score WLG from birth to 3 months, BMI, waist circumference, and subcutaneous fat were significantly higher; 0.51\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , 0.84\u2009cm, and 0.50\u2009mm, respectively. After multiple imputation, a trend towards significance was observed for intra-abdominal fat as well (0.51\u2009mm\/SD). In the associations with 5-year adiposity, no interaction between postnatal\n                    <jats:italic>Z<\/jats:italic>\n                    -score WLG and birth size was found.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Excess early postnatal weight gain is associated with increased general and central adiposity, characterized by more subcutaneous and likely more intra-abdominal fat at 5 years of age.\n                  <\/jats:p>","DOI":"10.1155\/2012\/141656","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T17:01:52Z","timestamp":1336582912000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children"],"prefix":"10.1155","volume":"2012","author":[{"given":"Annemieke M. V.","family":"Evelein","sequence":"first","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85060, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L. J.","family":"Visseren","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, University Medical Center Utrecht, P.O. Box 85500, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis K.","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederick E.","family":"Grobbee","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85060, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuno S. P. M.","family":"Uiterwaal","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. 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