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Treatment of animals with 500\u2009mg\/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500\u2009mg\/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of<jats:italic>Helicteres gardneriana<\/jats:italic>and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.<\/jats:p>","DOI":"10.1155\/2012\/141947","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T19:01:07Z","timestamp":1319050867000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Inhibitory Effect of<i>Helicteres gardneriana<\/i>Ethanol Extract on Acute Inflammation"],"prefix":"10.1155","volume":"2012","author":[{"given":"Juliana Oliveira","family":"de Melo","sequence":"first","affiliation":[{"name":"Laboratory of Inflammation, Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L\u00edcia Milani","family":"de 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