{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:28:58Z","timestamp":1792664938616,"version":"4.5.0"},"reference-count":142,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The bicuspid aortic valve is the most common congenital cardiac anomaly in developed nations. The abnormal bicuspid morphology of the aortic valve results in valvular dysfunction and subsequent hemodynamic derangements. However, the clinical presentation of bicuspid aortic valve disease remains quite heterogeneous with patients presenting from infancy to late adulthood with variable degrees of valvular stenosis and insufficiency and associated abnormalities including aortic coarctation, hypoplastic left heart structures, and ascending aortic dilatation. Emerging evidence suggests that the heterogeneous presentation of bicuspid aortic valve phenotypes may be a more complex matter related to congenital, genetic, and\/or connective tissue abnormalities. Optimal management of patients with BAV disease and associated ascending aortic aneurysms often requires a thoughtful approach, carefully assessing various risk factors of the aortic valve and the aorta and discerning individual indications for ongoing surveillance, medical management, and operative intervention. We review current concepts of anatomic classification, pathophysiology, natural history, and clinical management of bicuspid aortic valve disease with associated ascending aortic aneurysms.<\/jats:p>","DOI":"10.1155\/2012\/145202","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T21:00:34Z","timestamp":1351717234000},"page":"1-16","source":"Crossref","is-referenced-by-count":81,"title":["Bicuspid Aortic Valve Disease and Ascending Aortic Aneurysms: Gaps in Knowledge"],"prefix":"10.1155","volume":"2012","author":[{"given":"Katie L.","family":"Losenno","sequence":"first","affiliation":[{"name":"Department of Anatomy & Cell Biology, University of Western Ontario, London, ON, Canada N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W. 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